Department of Family Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Intern Med J. 2012 May;42(5):541-6. doi: 10.1111/j.1445-5994.2011.02644.x.
It has been observed that non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease and insulin resistance. Pulmonary function is also known to be related with cardiovascular disease and metabolic syndrome.
The objective of this study was to investigate the association between NAFLD and pulmonary function.
We performed a cross-sectional study to examine the association of NAFLD based on abdominal sonographic findings and pulmonary function in 2119 Korean men between the ages of 30 and 75. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) were compared according to the presence of NAFLD. Univariate and multivariate logistic regression analyses were conducted to evaluate the relationship of NAFLD with FVC and FEV(1) as pulmonary function tests.
The subjects with NAFLD had lower FVC and FEV(1) than their non-steatotic counterparts, and FVC and FEV(1) gradually decreased according to the grade of hepatic steatosis. After adjusting for age, body mass index, smoking status, blood pressure, fasting plasma glucose, total cholesterol, hypertension, diabetes, triglyceride and high-density lipoprotein cholesterol, the FVC and FEV(1) were found to be inversely associated with the presence of NAFLD.
NAFLD was independently associated with reduced pulmonary function, and the severity of NAFLD was inversely correlated with pulmonary function.
非酒精性脂肪性肝病（NAFLD）与心血管疾病和胰岛素抵抗的风险增加有关。已知肺功能也与心血管疾病和代谢综合征有关。
本研究旨在探讨 NAFLD 与肺功能之间的关系。
我们进行了一项横断面研究，以检查基于腹部超声结果的 NAFLD 与 2119 名年龄在 30 至 75 岁之间的韩国男性的肺功能之间的关联。根据是否存在 NAFLD 比较用力肺活量（FVC）和 1 秒用力呼气量（FEV1）。进行单变量和多变量逻辑回归分析，以评估 NAFLD 与 FVC 和 FEV1 作为肺功能测试的关系。
与非脂肪变性组相比，患有 NAFLD 的受试者的 FVC 和 FEV1 较低，并且随着肝脂肪变性程度的增加，FVC 和 FEV1 逐渐降低。在调整年龄、体重指数、吸烟状况、血压、空腹血糖、总胆固醇、高血压、糖尿病、甘油三酯和高密度脂蛋白胆固醇后，发现 FVC 和 FEV1 与 NAFLD 的存在呈负相关。
NAFLD 与肺功能降低独立相关，NAFLD 的严重程度与肺功能呈负相关。
