Qin Li, Zhang Weiwei, Yang Zhen, Niu Yixin, Li Xiaoyong, Lu Shuai, Xing Yin, Lin Ning, Zhang Hongmei, Ning Guang, Fan Jiangao, Su Qing
Department of Endocrinology, Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, China.
BMC Endocr Disord. 2017 Mar 22;17(1):18. doi: 10.1186/s12902-017-0168-4.
Associations between lung function and non-alcoholic fatty liver disease (NAFLD) have been reported. However, evidence from large-scale populations about the relationship is scarce. The objective of the study was to evaluate the relationship between lung function and NAFLD in middle-aged and elderly Chinese.
A total of 1842 participants aged 40 years or older were recruited from Chongming District, Shanghai, China. Lung function, evaluated by forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) was measured with standard spirometry. The NAFLD was evaluated by ultrasonography.
The subjects with NAFLD had lower FVC (% predicted) (0.85 ± 0.26 vs. 0.90 ± 0.28, p < 0.001) and FEV1 (% predicted) (0.93 ± 0.29 vs. 0.98 ± 0.34, p < 0.001) than non-NAFLD. After adjusting for potential risk factors, the lowest quartile of FVC (% predicted) and FEV1 (% predicted) was associated with increased prevalence of NAFLD, with the fully adjusted odds ratio of 1.37 and 1.24 (95% confidence interval [CI] 1.18-1.97, p < 0.001, 95% CI 1.11-1.87, p = 0.009), respectively.
Impaired lung function is associated with non-alcoholic fatty liver disease, independent of conventional metabolic risk factors.
已有报道称肺功能与非酒精性脂肪性肝病（NAFLD）之间存在关联。然而，来自大规模人群的关于二者关系的证据却很稀少。本研究的目的是评估中国中老年人群中肺功能与NAFLD之间的关系。
从中国上海崇明区招募了总共1842名年龄在40岁及以上的参与者。通过标准肺量计测量用力肺活量（FVC）和一秒用力呼气容积（FEV1）来评估肺功能。通过超声检查评估NAFLD。
与非NAFLD患者相比，NAFLD患者的FVC（预测值%）更低（0.85±0.26 vs. 0.90±0.28，p<0.001），FEV1（预测值%）也更低（0.93±0.29 vs. 0.98±0.34，p<0.001）。在对潜在风险因素进行校正后，FVC（预测值%）和FEV1（预测值%）的最低四分位数与NAFLD患病率增加相关，完全校正后的比值比分别为1.37和1.24（95%置信区间[CI] 1.18 - 1.97，p<0.001，95% CI 1.11 - 1.87，p = 0.009）。
肺功能受损与非酒精性脂肪性肝病相关，且独立于传统代谢风险因素。
