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预测前列腺癌根治性前列腺切除术后男性的勃起功能结局。

Predicting erectile function outcome in men after radical prostatectomy for prostate cancer.

机构信息

Institute of Naval Medicine, Alverstoke, UK.

出版信息

BJU Int. 2012 Aug;110(3):422-6. doi: 10.1111/j.1464-410X.2011.10757.x. Epub 2011 Dec 19.

Abstract

OBJECTIVE

• To identify the reported rates of potency after prostatectomy in the recent literature for men without preoperative erectile dysfunction (ED) and to develop a statistical model for predicting the expected potency after prostatectomy.

MATERIALS AND METHODS

• A Medline search was conducted with the keywords 'potency' and 'prostatectomy' from 2003 to 2009. • In total, 33 studies in the English language reporting pre- and postoperative erectile function were identified. • Data from studies reporting outcome after open, laparoscopic and robot-assisted prostatectomy were analyzed separately. • Only data obtained from potent men before surgery were included in the analysis.

RESULTS

• In potent men before surgery, the main predictors of post-treatment erectile function are age and time after treatment. • The cumulative range of potency rates at 48 months for all ages (45-75 years) was 49-74% for open, 58-74% for laparoscopic and 60-100% for robotic prostatectomy. • The predicted outcome differs by type of operation and patient age.

CONCLUSIONS

• Men aged <60 years have a significant likelihood of regaining erectile function after radical prostatectomy. • The reported statistical model provides a reliable estimation of erectile function outcome after prostatectomy for men with localized prostate cancer and intact erectile function.

摘要

目的

  • 确定近期文献中无术前勃起功能障碍(ED)的前列腺切除术后勃起功能的报告率,并建立预测前列腺切除术后预期勃起功能的统计模型。

材料与方法

  • 从 2003 年至 2009 年,使用“勃起功能”和“前列腺切除术”关键词进行 Medline 检索。

  • 共确定了 33 项报告术前和术后勃起功能的英文研究。

  • 分别分析开放、腹腔镜和机器人辅助前列腺切除术研究的数据。

  • 仅纳入分析术前勃起功能正常的研究数据。

结果

  • 在术前勃起功能正常的男性中,治疗后勃起功能的主要预测因素是年龄和治疗后时间。

  • 45-75 岁各年龄段所有手术方式 48 个月勃起功能率的累积范围为:开放手术 49-74%,腹腔镜手术 58-74%,机器人手术 60-100%。

  • 手术类型和患者年龄不同,预测结果也不同。

结论

  • <60 岁的男性在接受根治性前列腺切除术后,恢复勃起功能的可能性显著。

  • 报告的统计模型为局限性前列腺癌且勃起功能正常的男性提供了可靠的前列腺切除术后勃起功能预后估计。

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