S2 噬菌体素对铜绿假单胞菌生物膜的活性。
Activity of pyocin S2 against Pseudomonas aeruginosa biofilms.
机构信息
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2012 Mar;56(3):1599-601. doi: 10.1128/AAC.05714-11. Epub 2011 Dec 19.
Abstract
In cystic fibrosis patients, chronic lung infection with Pseudomonas aeruginosa and the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity against P. aeruginosa biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of P. aeruginosa infection, we also show that pyocin S2 is highly active in vivo.
摘要
在囊性纤维化患者中，铜绿假单胞菌的慢性肺部感染和随之而来的肺功能下降是导致死亡的主要原因。在本报告中，我们表明，噬菌体能有效地抑制铜绿假单胞菌生物膜，因此噬菌体能成为一种潜在的改良治疗选择。我们还利用一种铜绿假单胞菌感染的无脊椎动物模型表明，噬菌体能在体内具有高度活性。
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