Javed Ijaz, Faisal Imran, Rahman Ziaur, Khan Muhammad Zargham, Muhammad Faqir, Aslam Bilal, Ahmad Mahmood, Shahzadi Andleeb
Department of Physiology and Pharmacology, University of Agriculture Faisalabad, Pakistan.
Pak J Pharm Sci. 2012 Jan;25(1):141-7.
The purpose of the present study was to investigate the lipid lowering effect of Cinnamomum zeylanicum (Cinnamon) in hyperlipidaemic albino rabbits. For this purpose, forty eight albino rabbits were randomly divided into eight equal groups; untreated control on normal routine feed, untreated control on butter and cholesterol, treated control on synthetic cholesterol lowering drug simvastatin (Tablet survive (R) 20 mg), three treated groups on three respective doses of C. zeylanicum bark powder and two treated groups on water and methanol extracts of C. zeylanicum bark powder. Butter ad lib and cholesterol powder 500 mg/kg body weight were used to induce experimental hyperlipidaemia in all groups except untreated control group. The results suggested that C. zeylanicum bark powder at the rate of 0.50 g/kg, 0.75 g/kg and methanol extract equivalent to 0.75 g/kg powder produced respective percent reductions in total lipids by 45, 49 and 64; triglycerides by 38, 53 and 60; total cholesterol by 53, 64 and 69 and LDL-cholesterol by 50, 59 and 62. However, at these dosage levels HDL-cholesterol showed respective percent increase of 42, 48 and 53. Nonetheless, C. zeylanicum bark powder at the level of 0.25g/kg and C. zeylanicum extract in water could not significantly reduce lipid profile indicators. Based on these studies, it can safely be said that C. zeylanicum bark powder methanol extract equivalent to 0.75g/kg bark powder and simvastatin (0.6 mg/kg b. wt.) were equieffective in treating hyperlipidaemia.
本研究的目的是探讨锡兰肉桂对高脂血症白化兔的降脂作用。为此，将48只白化兔随机分为8组：正常常规饲料喂养的未治疗对照组、黄油和胆固醇喂养的未治疗对照组、服用合成降胆固醇药物辛伐他汀（舒降之（R）20mg片剂）的治疗对照组、分别服用三种剂量锡兰肉桂树皮粉的三个治疗组以及服用锡兰肉桂树皮粉水提取物和甲醇提取物的两个治疗组。除未治疗对照组外，所有组均使用自由采食的黄油和500mg/kg体重的胆固醇粉诱导实验性高脂血症。结果表明，锡兰肉桂树皮粉剂量为0.50g/kg、0.75g/kg以及相当于0.75g/kg粉末的甲醇提取物，总脂质分别降低了45%、49%和64%；甘油三酯分别降低了38%、53%和60%；总胆固醇分别降低了53%、64%和69%；低密度脂蛋白胆固醇分别降低了50%、59%和62%。然而，在这些剂量水平下，高密度脂蛋白胆固醇分别增加了42%、48%和53%。尽管如此，0.25g/kg水平的锡兰肉桂树皮粉和锡兰肉桂水提取物并不能显著降低血脂指标。基于这些研究，可以有把握地说，相当于0.75g/kg树皮粉的锡兰肉桂树皮粉甲醇提取物和辛伐他汀（0.6mg/kg体重）在治疗高脂血症方面具有同等疗效。
