Abeysekera Walimuni Prabhashini Kaushalya Mendis, Arachchige Sirimal Premakumara Galbada, Ratnasooriya Wanigasekera Daya
Herbal Technology Section (HTS), Modern Research & Development Complex (MRDC), Industrial Technology Institute (ITI), 503A Halbarawa Gardens, Malabe, Sri Lanka.
Department of Zoology, Faculty of Science, University of Colombo, Colombo, Sri Lanka.
Evid Based Complement Alternat Med. 2017;2017:7347219. doi: 10.1155/2017/7347219. Epub 2017 Jul 20.
Ethanol (95%) and dichloromethane : methanol (1 : 1) bark extracts of authenticated Ceylon cinnamon were investigated for range of antilipidemic activities (ALA): HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities and bile acids binding in vitro. Individual compounds in bark extracts were also evaluated. Bark extracts showed ALA in all the assays studied. The IC (g/mL) values ranged within 153.07 ± 8.38-277.13 ± 32.18, 297.57 ± 11.78-301.09 ± 4.05, 30.61 ± 0.79-34.05 ± 0.41, and 231.96 ± 9.22-478.89 ± 9.27, respectively, for HMG-CoA reductase, lipase, cholesterol esterase, and cholesterol micellization inhibitory activities. The bile acids binding (3 mg/mL) for taurocholate, glycodeoxycholate, and chenodeoxycholate ranged within 19.74 ± 0.31-20.22 ± 0.31, 21.97 ± 2.21-26.97 ± 1.61, and 16.11 ± 1.42-19.11 ± 1.52%, respectively. The observed ALA were moderate compared to the reference drugs studied. Individual compounds in bark extracts ranged within 2.14 ± 0.28-101.91 ± 3.61 and 0.42 ± 0.03-49.12 ± 1.89 mg/g of extract. Cinnamaldehyde and gallic acid were the highest and the lowest among the tested compounds. The ethanol extract had highest quantity of individual compounds and ALA investigated. Properties observed indicate usefulness of Ceylon cinnamon bark in managing hyperlipidemia and obesity worldwide. Further, this study provides scientific evidence for the traditional claim that Ceylon cinnamon has antilipidemic activities.
对经鉴定的锡兰肉桂的乙醇（95%）提取物以及二氯甲烷：甲醇（1：1）树皮提取物进行了一系列抗血脂活性（ALA）研究：体外研究了其对羟甲基戊二酸单酰辅酶A（HMG-CoA）还原酶、脂肪酶、胆固醇酯酶的活性，胆固醇胶束化抑制活性以及胆汁酸结合能力。还对树皮提取物中的个别化合物进行了评估。在所有研究的试验中，树皮提取物均显示出抗血脂活性。对于HMG-CoA还原酶、脂肪酶、胆固醇酯酶和胆固醇胶束化抑制活性，其半数抑制浓度（IC，μg/mL）值分别在153.07±8.38 - 277.13±32.18、297.57±11.78 - 301.09±4.05、30.61±0.79 - 34.05±0.41以及231.96±9.22 - 478.89±9.27范围内。对于牛磺胆酸盐、甘氨脱氧胆酸盐和鹅去氧胆酸盐，其胆汁酸结合能力（3mg/mL）分别在19.74±0.31 - 20.22±0.31%、21.97±2.21 - 26.97±1.61%以及16.11±1.42 - 19.11±1.52%范围内。与所研究的参考药物相比，观察到的抗血脂活性为中等水平。树皮提取物中的个别化合物含量在2.14±0.28 - 101.91±3.61mg/g提取物以及0.42±0.03 - 49.12±1.89mg/g提取物范围内。在所测试的化合物中，肉桂醛含量最高，没食子酸含量最低。乙醇提取物中所研究的个别化合物含量和抗血脂活性最高。观察到的特性表明锡兰肉桂树皮在全球管理高脂血症和肥胖症方面具有效用。此外，本研究为锡兰肉桂具有抗血脂活性这一传统说法提供了科学依据。
