Ranasinghe Priyanga, Pigera Shehani, Premakumara G A Sirimal, Galappaththy Priyadarshani, Constantine Godwin R, Katulanda Prasad
Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
BMC Complement Altern Med. 2013 Oct 22;13:275. doi: 10.1186/1472-6882-13-275.
In traditional medicine Cinnamon is considered a remedy for respiratory, digestive and gynaecological ailments. In-vitro and in-vivo studies from different parts of the world have demonstrated numerous beneficial medicinal effects of Cinnamomum zeylanicum (CZ). This paper aims to systematically review the scientific literature and provide a comprehensive summary on the potential medicinal benefits of CZ.
A comprehensive systematic review was conducted in the following databases; PubMed, Web of Science, SciVerse Scopus for studies published before 31st December 2012. The following keywords were used: "Cinnamomum zeylanicum", "Ceylon cinnamon", "True cinnamon" and "Sri Lankan cinnamon". To obtain additional data a manual search was performed using the reference lists of included articles.
The literature search identified the following number of articles in the respective databases; PubMed=54, Web of Science=76 and SciVerse Scopus=591. Thirteen additional articles were identified by searching reference lists. After removing duplicates the total number of articles included in the present review is 70. The beneficial health effects of CZ identified were; a) anti-microbial and anti-parasitic activity, b) lowering of blood glucose, blood pressure and serum cholesterol, c) anti-oxidant and free-radical scavenging properties, d) inhibition of tau aggregation and filament formation (hallmarks of Alzheimer's disease), e) inhibitory effects on osteoclastogenesis, f) anti-secretagogue and anti-gastric ulcer effects, g) anti-nociceptive and anti-inflammatory activity, h) wound healing properties and i) hepato-protective effects. The studies reported minimal toxic and adverse effects.
The available in-vitro and in-vivo evidence suggests that CZ has many beneficial health effects. However, since data on humans are sparse, randomized controlled trials in humans will be necessary to determine whether these effects have public health implications.
在传统医学中，肉桂被视为治疗呼吸道、消化系统和妇科疾病的药物。来自世界各地的体外和体内研究已经证明了锡兰肉桂（CZ）的多种有益药用功效。本文旨在系统回顾科学文献，并对CZ的潜在药用益处进行全面总结。
在以下数据库中进行了全面的系统回顾；截至2012年12月31日之前发表的研究的PubMed、科学网、SciVerse Scopus。使用了以下关键词：“锡兰肉桂”、“锡兰桂皮”、“真肉桂”和“斯里兰卡肉桂”。为了获取更多数据，使用纳入文章的参考文献列表进行了手动搜索。
文献检索在各个数据库中识别出以下数量的文章；PubMed = 54篇，科学网 = 76篇，SciVerse Scopus = 591篇。通过搜索参考文献列表又识别出13篇文章。去除重复项后，本综述纳入的文章总数为7篇。确定的CZ的有益健康作用有：a）抗菌和抗寄生虫活性，b）降低血糖、血压和血清胆固醇，c）抗氧化和清除自由基特性，d）抑制tau聚集和细丝形成（阿尔茨海默病的特征），e）对破骨细胞生成的抑制作用，f）抗促分泌和抗胃溃疡作用，g）抗伤害感受和抗炎活性，h）伤口愈合特性，i）肝脏保护作用。研究报告的毒性和不良反应最小。
现有的体外和体内证据表明，CZ有许多有益健康的作用。然而，由于关于人类的数据稀少，有必要在人类中进行随机对照试验，以确定这些作用是否具有公共卫生意义。
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