Elya Berna, Basah Katrin, Mun'im Abdul, Yuliastuti Wulan, Bangun Anastasia, Septiana Eva Kurnia
Department of Pharmacy, Faculty of Mathematics and Sciences, University of Indonesia, Depok 16424, Indonesia.
J Biomed Biotechnol. 2012;2012:281078. doi: 10.1155/2012/281078. Epub 2011 Dec 7.
Diabetes mellitus (DM) is recognized as a serious global health problem that is characterized by high blood sugar levels. Type 2 DM is more common in diabetic populations. In this type of DM, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. As a megabiodiversity country, Indonesia still has a lot of potential unexploited forests to be developed as a medicine source, including as the α-glucosidase inhibitor. In this study, we determine the α-glucosidase inhibitory activity of 80% ethanol extracts of leaves and twigs of some plants from the Apocynaceae, Clusiaceae, Euphorbiaceae, and Rubiaceae. Inhibitory activity test of the α-glucosidase was performed in vitro using spectrophotometric methods. Compared with the control acarbose (IC(50) 117.20 μg/mL), thirty-seven samples of forty-five were shown to be more potent α-glucosidase inhibitors with IC(50) values in the range 2.33-112.02 μg/mL.
糖尿病（DM）被公认为是一个严重的全球健康问题，其特征是血糖水平高。2型糖尿病在糖尿病患者群体中更为常见。在这类糖尿病中，抑制α-葡萄糖苷酶是延迟餐后葡萄糖吸收的一种有效治疗方法。作为一个生物多样性大国，印度尼西亚仍有许多未开发的森林有潜力被开发为药物来源，包括作为α-葡萄糖苷酶抑制剂。在本研究中，我们测定了夹竹桃科、藤黄科、大戟科和茜草科一些植物的叶和枝80%乙醇提取物的α-葡萄糖苷酶抑制活性。使用分光光度法在体外进行α-葡萄糖苷酶的抑制活性测试。与对照阿卡波糖（IC(50) 117.20μg/mL）相比，45个样品中的37个显示出更强的α-葡萄糖苷酶抑制活性，IC(50)值在2.33-112.02μg/mL范围内。
