Kaur Manjinder, Singh Harpreet, Ahuja G K
Department of Physiology, Geetanjali Medical College and Hospital, Udaipur 313001.
J Indian Med Assoc. 2011 Apr;109(4):234-7.
It is well known that post menopausal women are more prone to cardiovascular diseases, osteoporosis and cancer. This study was done to detect the effect of early onset of menopause on the cardiac performance in postmenopausal women. The cardiac functions were evaluated by the noninvasive technique of measuring systolic time intervals (STI) in the form of total electromechanical systolic time (OS2), left ventricular ejection time (LVET), pre-ejection period (PEP) and PEP/LVET ratio. The study included 50 postmenopausal women with age at the onset of menopause ranging from 29 years to 55 years, divided into three groups I, II and III with mean age at onset of menopause being 36.80 +/- 2.97, 43.97 +/- 2.97 and 52.05 +/- 1.61 years, respectively. In group I, there was a highly significant increase in QS2, PEP and PEP/LVET ratio and in group II, there is a significant decrease in LVET with a highly significant increase in PEP and PEP/LVET ratio. This signifies asymptomatic and subclinical cardiac systolic dysfunction in groups I and II as compared to group III. Early onset of menopause could thus be considered as a risk factor for increased cardiovascular morbidity; hence efforts should be made to timely detect and prevent these diseases in the postmenopausal stage.
众所周知，绝经后女性更容易患心血管疾病、骨质疏松症和癌症。本研究旨在检测绝经提前对绝经后女性心脏功能的影响。通过测量收缩期时间间期（STI）的非侵入性技术评估心脏功能，具体指标包括总电机械收缩期时间（OS2）、左心室射血时间（LVET）、射血前期（PEP）和PEP/LVET比值。该研究纳入了50名绝经后女性，绝经起始年龄在29岁至55岁之间，分为I、II和III三组，绝经起始平均年龄分别为36.80±2.97岁、43.97±2.97岁和52.05±1.61岁。在I组中，QS2、PEP和PEP/LVET比值显著升高；在II组中，LVET显著降低，而PEP和PEP/LVET比值显著升高。这表明与III组相比，I组和II组存在无症状和亚临床心脏收缩功能障碍。因此，绝经提前可被视为心血管疾病发病率增加的一个危险因素；因此，应努力在绝经后期及时检测和预防这些疾病。
