Kaur Manjinder, Ahuja G K, Singh Harpreet, Walia Lily, Avasthi Kum Kum
Departments of Physiology, Dayanand Medical College and Hospital, Ludhiana 141 001.
Indian J Physiol Pharmacol. 2010 Jan-Mar;54(1):80-4.
The incidence of ischemic heart disease is well documented in the literature in post menopausal women but the degree of deterioration of left ventricular performance in estrogen deficient state in women is not very clear. The present study was conducted to find the left ventricular performance by recording systolic time intervals (STIs) in 50 post menopausal women having either natural or surgical menopause and that was compared with 25 premenopausal controls. There was significant (P < 0.01) increase in QS2-I, PEP-I and PEP/LVET ratio but significant (P < 0.01) decrease in LVET-I in surgical menopause group whereas the natural menopause group showed less increase in QS2-I (P < 0.05), PEP/LVET ratio (P < 0.01) and decrease (P<0.01) in LVET-1. Thus, the performance of left ventricle is more affected in surgical menopause group as compared to natural menopause group. The ventricular dysfunction was observed by STIs prior to the appearance of clinical signs and symptoms.
缺血性心脏病的发病率在绝经后女性的文献中有充分记载，但女性雌激素缺乏状态下左心室功能恶化的程度尚不完全清楚。本研究通过记录50名自然绝经或手术绝经的绝经后女性的收缩期时间间期（STIs）来评估左心室功能，并与25名绝经前对照者进行比较。手术绝经组的QS2-I、PEP-I和PEP/LVET比值显著升高（P<0.01），而LVET-I显著降低（P<0.01）；自然绝经组的QS2-I升高幅度较小（P<0.05），PEP/LVET比值升高（P<0.01），LVET-I降低（P<0.01）。因此，与自然绝经组相比，手术绝经组的左心室功能受影响更大。在临床体征和症状出现之前，通过STIs就观察到了心室功能障碍。
