Lear Scott A, Deng Wei Q, Paré Guillaume, Sulistyoningrum Dian C, Loos Ruth J F, Devlin Angela
Faculty of Health Sciences, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Vancouver, British Columbia, Canada.
Genet Res (Camb). 2011 Dec;93(6):419-26. doi: 10.1017/S001667231100036X.
The fat mass and obesity associated (FTO) gene has been implicated with obesity and dietary intake predominantly in European populations. We assessed the association between the FTO rs9939609 variant with body fat distribution and dietary intake in a multi-ethnic population. Aboriginal, Chinese, European and South Asian participants living in Canada (n = 706) were assessed for body fat and inner-abdominal fat using imaging techniques, dietary intake and genotyped for the FTO rs9939609 variant. Linear regression was used to study the associations between the minor allele of the variant and measures of adiposity and dietary intake. Minor allele frequencies were: Aboriginals (17%), Chinese (17%), Europeans (39%) and South Asians (31%). The rs9939609 variant was associated with intake of dietary macronutrients in Aboriginals and Europeans only. In the total population, there were positive associations between the rs9939609 minor allele and greater fat mass (0.94 ± 0.56 kg, P = 0.045), per cent body fat (0.7 ± 0.4%, P = 0.031), relative greater subcutaneous abdominal adipose tissue (4.9 ± 2.8%, P = 0.039) and percent daily calories from fat (0.4 ± 0.2%, P = 0.064). Our findings suggest that the FTO rs9939609 minor allele may be associated with dietary intake in adults and is positively associated with regional fat deposition.
脂肪量和肥胖相关（FTO）基因主要在欧洲人群中被认为与肥胖和饮食摄入有关。我们评估了多民族人群中FTO rs9939609变异与体脂分布和饮食摄入之间的关联。对居住在加拿大的原住民、华裔、欧洲裔和南亚裔参与者（n = 706）使用成像技术评估体脂和腹部内脂肪，评估饮食摄入，并对FTO rs9939609变异进行基因分型。采用线性回归研究该变异的次要等位基因与肥胖指标和饮食摄入之间的关联。次要等位基因频率分别为：原住民（17%）、华裔（17%）、欧洲裔（39%）和南亚裔（31%）。rs9939609变异仅与原住民和欧洲裔的膳食常量营养素摄入有关。在总人群中，rs9939609次要等位基因与更高的脂肪量（0.94±0.56千克，P = 0.045）、体脂百分比（0.7±0.4%，P = 0.031）、相对更高的腹部皮下脂肪组织（4.9±2.8%，P = 0.039）以及每日脂肪热量百分比（0.4±0.2%，P = 0.064）呈正相关。我们的研究结果表明，FTO rs9939609次要等位基因可能与成年人的饮食摄入有关，并且与局部脂肪沉积呈正相关。
