Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain.
Int J Obes (Lond). 2011 Jan;35(1):66-71. doi: 10.1038/ijo.2010.219. Epub 2010 Oct 26.
We examined the association between the FTO rs9939609 polymorphism and serum leptin concentrations in adolescents. The FTO rs9939609 polymorphism was genotyped, and fasting serum leptin and insulin were measured in 655 European adolescents (365 females) aged 14.6 ± 1.2 years. We measured weight, height, triceps and subscapular skinfolds and waist circumference, and body fat percentage was calculated. Sex, pubertal status, center, physical activity (accelerometry), total or central adiposity and serum insulin concentrations were entered as confounders in the analyses. The minor A allele of the FTO rs9939609 was significantly associated with higher serum leptin concentrations independently of potential confounders including adiposity (+3.9 ng ml(-1) per risk allele (95% confidence interval: 2.0, 5.9); adjusted P < 0.001). These findings could link the FTO gene with serum leptin and consequently with the control of energy balance. Leptin could be a possible intermediary contributing to the association between the FTO rs9939609 polymorphism and adiposity.
我们研究了 FTO rs9939609 多态性与青少年血清瘦素浓度之间的关系。在 655 名年龄为 14.6±1.2 岁的欧洲青少年（365 名女性）中，对 FTO rs9939609 多态性进行了基因分型，并测量了空腹血清瘦素和胰岛素。我们测量了体重、身高、肱三头肌和肩胛下皮褶厚度以及腰围，并计算了体脂肪百分比。在分析中，将性别、青春期状态、中心、体力活动（加速度计）、全身或中心肥胖和血清胰岛素浓度作为混杂因素纳入。FTO rs9939609 的次要 A 等位基因与血清瘦素浓度显著相关，独立于潜在混杂因素，包括肥胖症（每风险等位基因增加 3.9ng/ml（95%置信区间：2.0，5.9）；调整后的 P<0.001）。这些发现可能将 FTO 基因与血清瘦素联系起来，进而与能量平衡的控制联系起来。瘦素可能是导致 FTO rs9939609 多态性与肥胖之间关联的一个可能的中介因素。
