Ram Hari, Mohammad Shadab, Husain Nuzhat, Gupta Prem Narayan
J Maxillofac Oral Surg. 2010 Dec;9(4):415-9. doi: 10.1007/s12663-010-0169-6. Epub 2011 Mar 17.
Ameloblastic carcinoma (AC) is a rare aggressive malignant epithelial odontogenic tumor of the maxillofacial skeleton with a distinct predilection in the mandible. It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst. It exhibits cytological features of ameloblastoma and carcinoma. It may present as a cystic lesion with benign clinical features or as a large tissue mass with ulceration, significant bone resorption and tooth mobility. The clinical course of ameloblastic carcinoma is typically aggressive, with extensive local destruction. Direct extension of the tumour, lymph node involvement and metastasis to various sites has been reported. Wide local excision is the treatment of choice. Regional lymph node dissection should be considered and performed selectively. Radiotherapy and chemotherapy have limited role in the treatment of ameloblastic carcinomas. Close periodic reassessment of the patient is mandatory.
成釉细胞癌（AC）是一种罕见的侵袭性恶性上皮性牙源性肿瘤，位于颌面部骨骼，在下颌骨有明显的偏好性。它可能原发出现，或起源于先前存在的成釉细胞瘤或牙源性囊肿。它具有成釉细胞瘤和癌的细胞学特征。它可能表现为具有良性临床特征的囊性病变，或表现为伴有溃疡、明显骨吸收和牙齿松动的大组织肿块。成釉细胞癌的临床病程通常具有侵袭性，会造成广泛的局部破坏。已有肿瘤直接蔓延、淋巴结受累及转移至各个部位的报道。广泛局部切除是首选的治疗方法。应考虑并选择性地进行区域淋巴结清扫。放疗和化疗在成釉细胞癌的治疗中作用有限。必须对患者进行定期密切复查。
