Department of Epidemiology and Preventive Medicine, Institute for Genome Sciences, University of Maryland School of Medicine, BioPark Building II, 801 West Baltimore Street, Baltimore, MD 21201, USA.
Sex Transm Infect. 2010 Aug;86(4):297-302. doi: 10.1136/sti.2009.040592.
The aetiology of bacterial vaginosis (BV) remains unknown.
To describe longitudinal changes in vaginal microbiota.
Thirty-nine women (mean age 36.8 years; 22 (56.4%) African-American) self-collected vaginal specimens twice weekly for 16 weeks as part of a vaginal douching cessation study. In an analysis where each woman serves as her own control, conditional logistic regression was used to evaluate daily, time-varying factors associated with a woman's incident BV episode(s) as compared with her persistently BV-negative sample(s). BV was defined by a Nugent's Gram stain score >or=7.
46.2% of participants had BV in the first 4 weeks of observation. Rapid fluctuation of vaginal microbiota was observed in 226 transitions to BV or spontaneous remission. Duration of BV was often short: 51% of the episodes lasted for only one sample interval (3 days). Among women who had at least one BV episode, the median number of episodes per woman was 8.7 (SD 7.4, range 1-22). Lubricant use 1 day before specimen collection (adjusted OR (aOR)=11.75, 95% CI 1.96 to 70.27) and rectal sex 2 days before (aOR=4.48, 95% CI 2.79 to 7.17) were associated with BV onset.
Rapid fluctuation of the vaginal microbiota was seen. Longitudinal studies with long intervals between sampling are likely to miss episodes of BV. Recent report of lubricant use and rectal sex were associated with incident BV.
细菌性阴道病（BV）的病因尚不清楚。
描述阴道微生物群的纵向变化。
39 名女性（平均年龄 36.8 岁；22 名（56.4%）为非裔美国人）作为阴道灌洗停止研究的一部分，每周自我采集阴道标本两次，共 16 周。在每个女性作为自己对照的分析中，使用条件逻辑回归评估与女性 BV 发作（s）相关的每日、时变因素，与她持续 BV 阴性样本（s）相比。BV 通过 Nugent 革兰氏染色评分>或=7 来定义。
46.2%的参与者在观察的前 4 周内患有 BV。在 226 次向 BV 或自发缓解的转变中观察到阴道微生物群的快速波动。BV 的持续时间通常很短：51%的发作仅持续一个样本间隔（3 天）。在至少有一次 BV 发作的女性中，每位女性的平均发作次数为 8.7（SD 7.4，范围 1-22）。在标本采集前 1 天使用润滑剂（调整后的 OR（aOR）=11.75，95%CI 1.96 至 70.27）和直肠性（aOR=4.48，95%CI 2.79 至 7.17）与 BV 发作相关。
观察到阴道微生物群的快速波动。在两次采样之间间隔较长的纵向研究中，可能会错过 BV 发作的病例。最近有报道称使用润滑剂和直肠性与 BV 的发生有关。
