从肿瘤免疫抑制到根除：靶向免疫效应细胞归巢至肿瘤及其在肿瘤中的活性
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
作者信息
Draghiciu Oana, Nijman Hans W, Daemen Toos
机构信息
Department of Medical Microbiology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
出版信息
Clin Dev Immunol. 2011;2011:439053. doi: 10.1155/2011/439053. Epub 2011 Dec 8.
Abstract
Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors.
摘要
揭示免疫系统对抗癌症发展所使用的机制是免疫学中最具挑战性的任务之一。关于肿瘤微环境中诱导耐受和免疫抑制机制的详细知识将有助于制定高效的肿瘤根除策略。过去几十年的研究使人们对这一问题有了更深入的了解。本文旨在概述肿瘤微环境中引发的主要耐受和免疫抑制机制的当前知识，重点是开发有效的免疫治疗策略，以改善免疫效应细胞向肿瘤的归巢和活性。
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