Vascular Biology and Autonomic Studies Laboratory, Appalachian State University, Boone, NC 28608, USA.
Oxid Med Cell Longev. 2011;2011:210798. doi: 10.1155/2011/210798. Epub 2011 Dec 4.
Antioxidants can decrease oxidative stress and combined with acute exercise they may lead to further decreases in blood pressure. The purpose of this study was to investigate the effects of 2 weeks of antioxidant supplementation on vascular distensibility and cardiovascular hemodynamics during postexercise hypotension.
Twenty young subjects were randomized to placebo (n = 10) or antioxidant supplementation (n = 10) for two weeks. Antioxidant status, vascular distensibility, and hemodynamics were obtained before, immediately, and 30 minutes after an acute bout of aerobic exercise both before and after supplementation.
Two weeks of antioxidant supplementation resulted in a greater systolic blood pressure (SBP) decrease during postexercise hypotension (PEH) and significant decreases in augmentation index versus placebo (12.5% versus 3.5%, resp.). Also ferric-reducing ability of plasma (FRAP) increased significantly (interaction P = 0.024) after supplementation.
Supplementation showed an additive effect on PEH associated with increased FRAP values and decreases in systolic blood pressure and augmentation index.
抗氧化剂可以减少氧化应激，与急性运动相结合，可能会导致血压进一步降低。本研究的目的是研究抗氧化剂补充 2 周对运动后低血压期间血管扩张性和心血管血液动力学的影响。
20 名年轻受试者随机分为安慰剂组（n = 10）或抗氧化剂补充组（n = 10），补充 2 周。在补充前后，分别在急性有氧运动前后即刻和 30 分钟时获得抗氧化状态、血管扩张性和血液动力学。
抗氧化剂补充 2 周导致运动后低血压（PEH）期间的收缩压（SBP）下降更大，与安慰剂相比，增强指数显著下降（12.5%对 3.5%，分别）。此外，血浆铁还原能力（FRAP）在补充后显著增加（交互 P = 0.024）。
补充剂对与 FRAP 值增加、收缩压和增强指数降低相关的 PEH 表现出附加效应。
