Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, and Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, United States.
Mutat Res. 2012 May 1;733(1-2):78-82. doi: 10.1016/j.mrfmmm.2011.12.002. Epub 2011 Dec 13.
Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential. There is no data indicating that trivalent chromium promotes genomic stability and, instead may promote genomic instability. Hexavalent chromium is widely accepted as highly toxic and carcinogenic with no nutritional value. Recent data indicate that it causes genomic instability and also has no role in promoting genomic stability.
许多金属作为微量元素，可防止基因组不稳定。铬有三价和六价两种形式，其中三价铬含量最高。三价铬过去一直被认为是一种必需元素，但最近的数据表明，虽然它可能具有药理作用和价值，但并非必需。没有数据表明三价铬可促进基因组稳定，反而可能促进基因组不稳定。六价铬被广泛认为具有高度毒性和致癌性，且无营养价值。最近的数据表明，它会导致基因组不稳定，也没有促进基因组稳定的作用。
