Department of Nephrology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People's Republic of China.
Clin Rheumatol. 2012 Apr;31(4):669-75. doi: 10.1007/s10067-011-1910-3. Epub 2011 Dec 23.
Cardiovascular disease (CVD) is one of the most serious complications of systemic lupus erythematosus (SLE). This study investigated the frequency of established CVD and its associated risk factors in Chinese patients with SLE. A retrospective, cross-sectional analysis was conducted of 1,072 consecutive patients with SLE from a single center. Patients with CVD were identified on the basis of medical record documentation. Stepwise multivariate logistic regression was used to assess the risk factors of CVD. Of the 1,072 patients with SLE, 71 (6.6%) had CVD. Patients with CVD were older than patients without CVD (39.0 ± 15.6 vs. 31.9 ± 13.3 years; P < 0.001), the frequency of CVD in patients aged ≤19 years, between 20 and 39 years, between 40 and 69 years, and greater than 60 years was increased by 3.4%, 5.5%, 9.2%, 20.4%, respectively. The frequency of CVD was higher in SLE patients with nephritis than without nephritis (7.6% vs. 3.8%; P = 0.026). Multivariate regression analyses confirmed that age ≥60 years (OR = 5.098; 95% CI 1.333, 19.488), higher diastolic blood pressure (OR = 1.050; 95% CI 1.022, 1.078), higher serum creatinine levels (OR = 1.002; 95% CI 1.000, 1.003), and long-term use of glucocorticoids (OR = 1.005; 95% CI 1.000, 1.010) were risk factors for CVD. HDL-C levels (OR = 0.121; 95% CI 0.041, 0.358) were negatively associated with CVD in patients with SLE. Our data suggest that the frequency of CVD was high in Chinese patients with SLE, and independent risk factors for CVD were increased age, higher diastolic blood pressure, higher serum creatinine levels, long-term use of glucocorticoids, and lower HDL-C levels.
心血管疾病（CVD）是系统性红斑狼疮（SLE）最严重的并发症之一。本研究旨在调查中国 SLE 患者 CVD 的发生率及其相关危险因素。对单中心的 1072 例连续 SLE 患者进行回顾性、横断面分析。根据病历记录确定 CVD 患者。采用逐步多元逻辑回归评估 CVD 的危险因素。在 1072 例 SLE 患者中，71 例（6.6%）患有 CVD。患有 CVD 的患者比未患有 CVD 的患者年龄更大（39.0 ± 15.6 岁比 31.9 ± 13.3 岁；P < 0.001），年龄≤19 岁、20-39 岁、40-69 岁和>60 岁的患者 CVD 发生率分别增加 3.4%、5.5%、9.2%和 20.4%。肾炎患者的 CVD 发生率高于无肾炎患者（7.6%比 3.8%；P = 0.026）。多变量回归分析证实，年龄≥60 岁（OR = 5.098；95% CI 1.333, 19.488）、舒张压更高（OR = 1.050；95% CI 1.022, 1.078）、血清肌酐水平更高（OR = 1.002；95% CI 1.000, 1.003）和长期使用糖皮质激素（OR = 1.005；95% CI 1.000, 1.010）是 CVD 的危险因素。HDL-C 水平（OR = 0.121；95% CI 0.041, 0.358）与 SLE 患者的 CVD 呈负相关。我们的数据表明，中国 SLE 患者 CVD 的发生率较高，CVD 的独立危险因素包括年龄增长、舒张压升高、血清肌酐水平升高、长期使用糖皮质激素和 HDL-C 水平降低。
