Department of Internal Medicine, University of California Riverside, 900 University Ave, Riverside, CA, 92521, USA.
Office of Research, Riverside University Health System, 26520 Cactus Avenue - Education Building, Moreno Valley, CA, 92555, USA.
Clin Rheumatol. 2019 Feb;38(2):597-600. doi: 10.1007/s10067-018-4336-3. Epub 2018 Oct 24.
The role of obesity in systemic lupus erythematosus (SLE) remains controversial. Studies have linked adiposity with a heightened risk of clinical complications including neurocognitive decline, renal impairment, dampened physical activity, and depressed quality of life-but not disease activity. We aimed to reexamine whether obesity in SLE patients independently associates with higher disease activity. Adult patients with SLE were recruited from the longitudinal, multi-ethnic Southern California Lupus Registry (SCOLR). Disease status was ascertained by calculating SLE Disease Activity Index (SLEDAI), which was then statistically analyzed for association with increased body mass index (BMI) by univariable and multivariable regression analyses. One hundred and thirty-seven patients were included in the study; 37% were obese (BMI ≥ 30 kg/m). Obesity was significantly associated with SLEDAI (P = 0.026) and current steroid use (P = 0.029). Multivariable regression analysis demonstrated that obesity remained independently associated with lupus activity (OR 2.335, P = 0.026). In a representative sample of patients with SLE, obesity independently associated with worse SLE disease activity. Obesity may therefore be an important target for improving SLE outcomes.
肥胖在系统性红斑狼疮 (SLE) 中的作用仍存在争议。研究表明，肥胖与多种临床并发症的风险增加有关，包括认知功能下降、肾功能损害、体力活动减少和生活质量下降，但与疾病活动无关。我们旨在重新评估肥胖是否与 SLE 患者的疾病活动增加独立相关。从纵向、多民族南加州狼疮登记处 (SCOLR) 招募了成年 SLE 患者。通过计算 SLE 疾病活动指数 (SLEDAI) 来确定疾病状况，然后通过单变量和多变量回归分析对与体重指数 (BMI) 增加相关的 SLEDAI 进行统计学分析。本研究共纳入 137 例患者，其中 37%为肥胖患者 (BMI≥30kg/m)。肥胖与 SLEDAI (P=0.026) 和当前使用类固醇 (P=0.029) 显著相关。多变量回归分析表明，肥胖与狼疮活动仍独立相关 (OR 2.335，P=0.026)。在 SLE 患者的代表性样本中，肥胖与 SLE 疾病活动的恶化独立相关。因此，肥胖可能是改善 SLE 结局的一个重要目标。
