Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
J Infect Dis. 2012 Feb 15;205(4):680-3. doi: 10.1093/infdis/jir806. Epub 2011 Dec 22.
In a prospective infant cohort, 21 infants developed Plasmodium vivax malaria during their first year. Twelve of their mothers also had vivax malaria in the corresponding pregnancies or postpartum period. The genotypes of the maternal and infant infections were all different. Eight of the 12 mothers and 9 of the 21 infants had recurrent infections. Relapse parasite genotypes were different to the initial infection in 13 of 20 (65%) mothers compared with 5 of 24 (21%) infants (P = .02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations.
在一项前瞻性婴儿队列研究中，21 名婴儿在其一岁内患上了间日疟原虫疟疾。其中 12 名婴儿的母亲在相应的孕期或产后也患有间日疟。母婴感染的基因型均不同。12 名母亲中有 8 人、21 名婴儿中有 9 人出现了反复感染。与 24 名婴儿中的 5 名（21%）相比，20 名母亲中有 13 名（65%）的复发寄生虫基因型与初始感染不同（P=.02）。一生中的第一次间日疟原虫复发通常在遗传上是同源的，而成年人的复发可能是由于先前接种激活了异源潜伏休眠子。
