1α,25-二羟维生素 D(3)及其类似物 2-亚甲基-19-去甲-(20S)-1α,25-二羟维生素 D(3)(2MD)可降低非人灵长类动物的眼内压。
1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates.
机构信息
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706-1544, United States.
出版信息
Arch Biochem Biophys. 2012 Feb 1;518(1):53-60. doi: 10.1016/j.abb.2011.10.022. Epub 2011 Dec 16.
Abstract
Ocular hypertension is the greatest known risk factor for glaucoma that affects an estimated 70 million people worldwide. Lowering intraocular pressure (IOP) remains the mainstay of therapy in the management of glaucoma. By means of microarray analysis, we have discovered that 1α,25-dihydroxyvitamin D(3) (1α,25-(OH)(2)D(3)) regulates genes that are known to be involved in the determination of intraocular pressure (IOP). Topical administration of 1α,25-(OH)(2)D(3) or its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), markedly reduces IOP in non-human primates. The reduction in IOP is not the result of reduced aqueous humor formation, while a 35% increase in aqueous humor drainage by 1α,25-(OH)(2)D(3) was found but this increase did not achieve significance. Nevertheless, our results suggest that 1α,25-(OH)(2)D(3), or an analog thereof, may present a new approach to the treatment of glaucoma.
摘要
眼内高压是目前已知的、对全球约 7000 万人产生影响的青光眼最大风险因素。降低眼内压（IOP）仍然是青光眼治疗的主要方法。通过微阵列分析，我们发现 1α,25-二羟维生素 D(3)（1α,25-(OH)(2)D(3)）调节已知参与眼压（IOP）决定的基因。局部给予 1α,25-(OH)(2)D(3)或其类似物，2-亚甲基-19-降-（20S）-1α,25-二羟维生素 D(3)（2MD），可显著降低非人灵长类动物的眼内压。IOP 的降低不是房水形成减少的结果，而发现 1α,25-(OH)(2)D(3)可使房水引流增加 35%，但这一增加没有达到显著水平。尽管如此，我们的结果表明，1α,25-(OH)(2)D(3)或其类似物可能为治疗青光眼提供一种新方法。
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