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心血管疾病与牙周炎之间是否存在因果关系?

Does a causal relation between cardiovascular disease and periodontitis exist?

机构信息

Institute for Inflammation Research, Department of Infectious Medicine and Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

出版信息

Microbes Infect. 2012 May;14(5):411-8. doi: 10.1016/j.micinf.2011.12.004. Epub 2011 Dec 13.

DOI:10.1016/j.micinf.2011.12.004
PMID:22200601
Abstract

Inflammation is believed to play a central part in the pathogenesis of atherosclerosis, and much attention has been paid to the possible association between atherosclerosis and other inflammatory diseases. Periodontal disease is a common inflammatory disease affecting up to 50% of the adult population, and during the past two decades much research has focused on a possible association between periodontitis and cardiovascular disease. Here, we review the existing literature on the association between the two diseases.

摘要

炎症被认为在动脉粥样硬化的发病机制中起着核心作用,因此人们非常关注动脉粥样硬化与其他炎症性疾病之间的可能关联。牙周病是一种常见的炎症性疾病,影响到多达 50%的成年人口,在过去的二十年中,大量研究集中在牙周炎和心血管疾病之间的可能关联上。在这里,我们回顾了关于这两种疾病之间关联的现有文献。

相似文献

1
Does a causal relation between cardiovascular disease and periodontitis exist?心血管疾病与牙周炎之间是否存在因果关系?
Microbes Infect. 2012 May;14(5):411-8. doi: 10.1016/j.micinf.2011.12.004. Epub 2011 Dec 13.
2
[Periodontitis : An underestimated risk of cardiovascular diseases].[牙周炎:心血管疾病被低估的风险]
Med Sci (Paris). 2024 Jan;40(1):35-41. doi: 10.1051/medsci/2023193. Epub 2024 Feb 1.
3
Periodontal and atherosclerosis-induced diseases.牙周病和动脉粥样硬化引发的疾病。
Int Angiol. 2007 Sep;26(3):197-205.
4
The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review.牙周疾病与心血管疾病之间的关联:科学现状综述
Ann Periodontol. 2001 Dec;6(1):9-15. doi: 10.1902/annals.2001.6.1.9.
5
Treatment of Periodontitis for the Prevention of Endothelial Dysfunction: A Narrative Review.治疗牙周炎以预防内皮功能障碍:一项叙述性综述。
Curr Vasc Pharmacol. 2015;13(6):749-58. doi: 10.2174/1570161113666150818110653.
6
[The impact of periodontal infection on systemic inflammatory process and atherosclerosis].[牙周感染对全身炎症过程和动脉粥样硬化的影响]
Przegl Lek. 2006;63(8):681-4.
7
Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease.牙周炎的全身影响:牙周病与心血管疾病的流行病学
J Periodontol. 2005 Nov;76(11 Suppl):2089-100. doi: 10.1902/jop.2005.76.11-S.2089.
8
[Correlations between dental-oral infections and cardiovascular disease].[口腔感染与心血管疾病之间的相关性]
Fogorv Sz. 2008 Jun;101(3):101-5.
9
[Marginal periodontitis and cardiovascular diseases].
Schweiz Monatsschr Zahnmed. 2001;111(4):445-54.
10
Abdominal obesity modifies long-term associations between periodontitis and markers of systemic inflammation.腹部肥胖改变了牙周炎与全身炎症标志物之间的长期关联。
Atherosclerosis. 2014 Aug;235(2):351-7. doi: 10.1016/j.atherosclerosis.2014.05.926. Epub 2014 May 22.

引用本文的文献

1
Oleogel-based drug delivery for the treatment of periodontitis: current strategies and future perspectives.基于油凝胶的牙周炎治疗药物递送:当前策略和未来展望。
F1000Res. 2023 Sep 27;12:1228. doi: 10.12688/f1000research.140173.1. eCollection 2023.
2
Cardiovascular Diseases and Periodontitis.心血管疾病与牙周炎
Adv Exp Med Biol. 2022;1373:261-280. doi: 10.1007/978-3-030-96881-6_14.
3
Oral health and all-cause, cardiovascular disease, and respiratory mortality in older people in the UK and USA.英国和美国老年人的口腔健康与全因、心血管疾病和呼吸道死亡率。
Sci Rep. 2021 Aug 12;11(1):16452. doi: 10.1038/s41598-021-95865-z.
4
Associations between Pharmacotherapy for Cardiovascular Diseases and Periodontitis.心血管疾病药物治疗与牙周炎的关联。
Int J Environ Res Public Health. 2021 Jan 18;18(2):770. doi: 10.3390/ijerph18020770.
5
Deletion of a conserved transcript PG_RS02100 expressed during logarithmic growth in Porphyromonas gingivalis results in hyperpigmentation and increased tolerance to oxidative stress.缺失在牙龈卟啉单胞菌对数生长期表达的保守转录本 PG_RS02100 导致过度色素沉着和增加对氧化应激的耐受性。
PLoS One. 2018 Nov 12;13(11):e0207295. doi: 10.1371/journal.pone.0207295. eCollection 2018.
6
Periodontitis in patients with cirrhosis: a cross-sectional study.肝硬化患者的牙周炎:一项横断面研究。
BMC Oral Health. 2018 Feb 13;18(1):22. doi: 10.1186/s12903-018-0487-5.
7
Immunoglobulin G antibodies against or in cardiovascular disease and periodontitis.针对心血管疾病和牙周炎的免疫球蛋白G抗体或存在于心血管疾病和牙周炎中的免疫球蛋白G抗体 。 (原英文表述不太完整准确,按字面意思翻译可能不太能完全清晰表达确切含义,推测可能是这个意思 )
J Oral Microbiol. 2017 Sep 10;9(1):1374154. doi: 10.1080/20002297.2017.1374154. eCollection 2017.
8
Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis.胆固醇晶体增强单核细胞对致动脉粥样硬化口腔细菌牙龈卟啉单胞菌的TLR2和TLR4介导的促炎细胞因子反应。
PLoS One. 2017 Feb 24;12(2):e0172773. doi: 10.1371/journal.pone.0172773. eCollection 2017.
9
Presence and consequence of tooth periapical radiolucency in patients with cirrhosis.肝硬化患者牙齿根尖周透射区的存在及其影响
Hepat Med. 2016 Sep 13;8:97-103. doi: 10.2147/HMER.S113485. eCollection 2016.
10
Periodontitis in Chronic Heart Failure.慢性心力衰竭中的牙周炎
Tex Heart Inst J. 2016 Aug 1;43(4):297-304. doi: 10.14503/THIJ-15-5200. eCollection 2016 Aug.