Jergens Albert E, Simpson Kenneth W
Department of Veterinary Clinical Sciences, Iowa State University, Ames, Iowa 50010, USA.
Front Biosci (Elite Ed). 2012 Jan 1;4(4):1404-19. doi: 10.2741/e470.
Canine and feline inflammatory bowel disease (IBD) denotes a heterogeneous group of idiopathic, chronic, relapsing inflammatory disorders of the gastrointestinal tract that are immunologically-mediated. While their exact etiologies remain unknown, results from basic science and clinical studies suggest that interplay between genetic factors and enteric bacteria are crucial for disease development, owing to abnormal host responses directed against the commensal microbiota. Key clinical signs include vomiting, diarrhea and weight loss, and histopathologic lesions of inflammation may involve the stomach, small intestine, or colon. Recent advances in molecular tools, disease activity indices, and biomarker development now permit objective assessment of IBD severity at diagnosis and in response to various therapies. Treatment of IBD involves both dietary and pharamacologic interventions as well as therapeutic manipulation of the enteric microbiota through the use of antibiotics and soluble fiber (prebiotic) supplements. Here we provide a comprehensive overview on the etiopathogenesis, clinical features, diagnosis strategies, current treatment recommendations, and outcomes from veterinary studies in dogs and cats with IBD. We also offer scientific comparison between human and canine IBD.
犬猫炎性肠病（IBD）是一组异质性的特发性、慢性、复发性胃肠道炎性疾病，由免疫介导。虽然其确切病因尚不清楚，但基础科学和临床研究结果表明，由于针对共生微生物群的宿主反应异常，遗传因素与肠道细菌之间的相互作用对疾病发展至关重要。主要临床症状包括呕吐、腹泻和体重减轻，炎症的组织病理学病变可能累及胃、小肠或结肠。分子工具、疾病活动指数和生物标志物开发方面的最新进展现在允许在诊断时和对各种治疗的反应中客观评估IBD的严重程度。IBD的治疗包括饮食和药物干预，以及通过使用抗生素和可溶性纤维（益生元）补充剂对肠道微生物群进行治疗性调控。在这里，我们全面概述了犬猫IBD的病因发病机制、临床特征、诊断策略、当前治疗建议以及兽医研究的结果。我们还对人类和犬类IBD进行了科学比较。
