Jahn Stephan Christopher, Law Mary Elizabeth, Corsino Patrick Evan, Law Brian Keith
Department of Pharmacology and Therapeutics, Shands Cancer Center, University of Florida, Gainesville, FL 32610, United States.
Front Biosci (Schol Ed). 2012 Jan 1;4(2):749-66. doi: 10.2741/s297.
The TGF-beta signaling pathway controls multiple functions of cancer cells and the surrounding stromal tissue. Some TGF-beta actions suppress cancer formation, while others contribute to tumor progression. Evidence supporting a tumor suppressive role for the TGF-beta/Smad signaling axis is presented here. These data are compiled from cell culture studies, animal models, analyses of human tumors, and investigations of polymorphisms of TGF-beta pathway components and their associated cancer risk. Therapeutic strategies for cancer treatment involving either restoring or potentiating TGF-beta tumor suppressive activities, or blocking TGF-beta tumor promoting functions are considered.
转化生长因子-β（TGF-β）信号通路控制着癌细胞和周围基质组织的多种功能。TGF-β的一些作用可抑制癌症形成，而其他作用则促进肿瘤进展。本文提供了支持TGF-β/Smad信号轴具有肿瘤抑制作用的证据。这些数据来自细胞培养研究、动物模型、人类肿瘤分析以及对TGF-β通路成分多态性及其相关癌症风险的调查。文中还考虑了涉及恢复或增强TGF-β肿瘤抑制活性，或阻断TGF-β肿瘤促进功能的癌症治疗策略。
