Telles Elphine, Seto Edward
Department of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Front Biosci (Schol Ed). 2012 Jan 1;4(3):831-9. doi: 10.2741/s303.
Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues on histones and non-histone proteins. HDACs have been shown to control the functions of key cell cycle proteins. Consistent with this, the overexpression of HDACs has been observed in multiple cancers, resulting in deregulation of the cell cycle and uncontrolled proliferation. This review focuses on the impact that HDACs have on cell cycle control through the deacetylation of proteins.
组蛋白脱乙酰酶（HDACs）催化组蛋白和非组蛋白上赖氨酸残基的脱乙酰化反应。研究表明，HDACs可调控关键细胞周期蛋白的功能。与此相符的是，在多种癌症中均观察到HDACs的过表达，这导致细胞周期失调和细胞增殖失控。本综述聚焦于HDACs通过蛋白质脱乙酰化作用对细胞周期调控的影响。
