Department of Neurology, Center for Stroke Research Berlin & Cluster of Excellence NeuroCure, Charite, Universitätsmedizin Berlin, Berlin, Germany.
Arch Phys Med Rehabil. 2012 Jan;93(1 Suppl):S35-45. doi: 10.1016/j.apmr.2011.06.040.
Approaches for treating poststroke language impairments (aphasia) based on constraint-induced (CI) principles were first introduced in 2001. CI principles as previously applied to upper extremity and locomotor retraining in stroke survivors were derived from basic neuroscience. They comprise forced-use of the affected modality, a gradual rebuilding of targeted functions using a highly intensive treatment protocol, administered in a behaviorally relevant context. CI-based approaches have stimulated considerable neurorehabilitation research interest in the past decade. The original CI aphasia treatment protocol was tailored to improve functional communication in chronic aphasia (ie, 6-12mo after stroke) and more recently, it has been adapted to treat language impairments in acute stroke survivors as well. Moreover, CI therapy applied to aphasia has been used as a model to assess language network plasticity in response to treatment using functional imaging techniques. In the following article, we review the first 10 years of behavioral and functional brain imaging research on CI-based approaches for aphasia rehabilitation.
基于约束诱导（CI）原则治疗中风后语言障碍（失语症）的方法于 2001 年首次提出。以前应用于中风幸存者上肢和运动功能恢复的 CI 原则源于基础神经科学。它们包括强制使用受影响的模式，使用高度密集的治疗方案逐渐重建目标功能，并在行为相关的环境中进行。在过去的十年中，基于 CI 的方法激发了相当多的神经康复研究兴趣。最初的 CI 失语症治疗方案旨在改善慢性失语症（即中风后 6-12 个月）的功能性交流，最近，它也被改编用于治疗急性中风幸存者的语言障碍。此外，应用于失语症的 CI 疗法已被用作使用功能成像技术评估治疗反应中语言网络可塑性的模型。在本文中，我们回顾了过去 10 年基于 CI 的失语症康复方法的行为和功能脑成像研究。
