Kita M, Ogura Y, Honda Y, Hyon S H, Cha W I, Ikada Y
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Nippon Ganka Gakkai Zasshi. 1990 May;94(5):480-3.
A transparent polyvinyl alcohol (PVA) hydrogel was prepared from a PVA solution in a mixed solvent consisting of water and a water miscible organic solvent by cooling. The physical properties were evaluated in comparison with commercially available soft contact lens materials, such as polyhydroxyethyl methacrylate (PHEMA) and copolymers of methyl methacrylate (MMA) and N-vinyl pyrrolidone (VP). The PVA hydrogel showed higher tensile strength and elongation at break than the other materials, while it had high water content and oxygen permeability the latter being comparable to those of PMMA/VP copolymers. The protein adsorption of the PVA hydrogel was much less than those of the other materials. The PVA hydrogel soft contact lenses were applied on rabbit eyes for 12 weeks. The influence on the cornea was studied by biomicroscopy, ultrasonic corneal pachymetry and histopathological examination. These examinations revealed no abnormal findings in the cornea. These results suggest that the PVA hydrogel may be promising as a new soft contact lens material.
通过冷却由水和与水混溶的有机溶剂组成的混合溶剂中的聚乙烯醇（PVA）溶液，制备了一种透明的PVA水凝胶。与市售的软性隐形眼镜材料（如聚甲基丙烯酸羟乙酯（PHEMA）以及甲基丙烯酸甲酯（MMA）和N-乙烯基吡咯烷酮（VP）的共聚物）相比，对其物理性能进行了评估。PVA水凝胶显示出比其他材料更高的拉伸强度和断裂伸长率，同时具有高含水量和透氧性，后者与PMMA/VP共聚物相当。PVA水凝胶的蛋白质吸附比其他材料少得多。将PVA水凝胶软性隐形眼镜应用于兔眼12周。通过生物显微镜检查、超声角膜测厚法和组织病理学检查研究对角膜的影响。这些检查在角膜中未发现异常结果。这些结果表明，PVA水凝胶作为一种新型软性隐形眼镜材料可能很有前景。
