Kita M, Ogura Y, Honda Y, Hyon S H, Cha W, Ikada Y
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Graefes Arch Clin Exp Ophthalmol. 1990;228(6):533-7. doi: 10.1007/BF00918486.
We prepared a transparent polyvinyl alcohol (PVA) hydrogel from a PVA solution in a mixed solvent consisting of water and a water-miscible organic solvent by cooling. The physical properties of the hydrogel were evaluated in various mixed solvents and compared with those of commercially available soft contact lens materials, such as polyhydroxyethyl methacrylate (PHEMA) and copolymers of methylmethycrylate (MMA) and N-vinyl pyrrolidone (N-VP). The PVA hydrogel showed higher tensile strength and elongation before breaking than did the other materials. Also, the PVA hydrogel was comparable in its high water content and its oxygen permeability with the MMA/VP copolymers. The protein adsorption of the PVA hydrogel was much lower than that of the other materials. Soft contact lenses of PVA hydrogel were applied to rabbit eyes for 12 weeks. The effects of the lenses on the cornea were studied by biomicroscopy, ultrasonic pachymetry, and histopathologic examination. No abnormal findings were noted, suggesting that the PVA hydrogel may be promising as a new material for use in soft contact lenses.
我们通过冷却由水和与水混溶的有机溶剂组成的混合溶剂中的聚乙烯醇（PVA）溶液，制备了一种透明的PVA水凝胶。在各种混合溶剂中评估了该水凝胶的物理性质，并将其与市售的软性隐形眼镜材料（如聚甲基丙烯酸羟乙酯（PHEMA）以及甲基丙烯酸甲酯（MMA）和N-乙烯基吡咯烷酮（N-VP）的共聚物）的物理性质进行了比较。PVA水凝胶显示出比其他材料更高的拉伸强度和断裂前伸长率。此外，PVA水凝胶在高含水量和透氧性方面与MMA/VP共聚物相当。PVA水凝胶的蛋白质吸附比其他材料低得多。将PVA水凝胶软性隐形眼镜应用于兔眼12周。通过生物显微镜检查、超声测厚法和组织病理学检查研究了镜片对角膜的影响。未发现异常结果，这表明PVA水凝胶作为一种用于软性隐形眼镜的新材料可能很有前景。
