Gadin Erlita, Lobo Michele, Paul David A, Sem Kanik, Steiner Karl V, Mackley Amy, Anzilotti Kert, Galloway Cole
Department of Pediatrics, Christiana Care Health System, Newark, Delaware, USA.
Pediatr Phys Ther. 2012 Spring;24(1):38-44. doi: 10.1097/PEP.0b013e31823e069d.
To investigate the relationship between volumetric magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in infants born less than 30 weeks gestation and early motor development at 6 months adjusted age.
Twenty infants born preterm and 4 born at term (control) underwent MRI with volumetric analysis and MRS prior to neonatal intensive care unit discharge. Infants were assessed using the Bayley Scale of Infant Development at 6 months adjusted age.
At 6 months, infants born preterm with low motor scores had a reduction in their subcortical gray matter. No differences were detected in other brain structures. N-acetylaspartate/choline correlated with white matter (R = 0.45, P = .03), gray matter (R = 0.43, P = .04), and cerebellar volume (R = 0.6, P = .002) but not with 6-month motor performance.
There is an association between diminished subcortical gray matter volume and low motor scores. Our data suggest that volumetric MRI performed prior to hospital discharge may have some role in counseling parents about potential motor delays.
研究孕周小于30周的早产婴儿的容积磁共振成像（MRI）和磁共振波谱（MRS）与矫正年龄6个月时早期运动发育之间的关系。
20名早产婴儿和4名足月儿（对照）在新生儿重症监护病房出院前接受了MRI容积分析和MRS检查。在矫正年龄6个月时，使用贝利婴儿发育量表对婴儿进行评估。
在6个月时，运动评分低的早产婴儿皮质下灰质减少。在其他脑结构中未检测到差异。N-乙酰天门冬氨酸/胆碱与白质（R = 0.45，P = 0.03）、灰质（R = 0.43，P = 0.04）和小脑容积（R = 0.6，P = 0.002）相关，但与6个月时的运动表现无关。
皮质下灰质容积减少与运动评分低之间存在关联。我们的数据表明，出院前进行的容积MRI检查可能在向家长咨询潜在运动发育迟缓方面具有一定作用。
