Bapat Roopali, Narayana Ponnada A, Zhou Yuxiang, Parikh Nehal A
Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital and The Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio.
Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center, Houston, Texas.
Pediatr Neurol. 2014 Jul;51(1):53-9. doi: 10.1016/j.pediatrneurol.2014.03.011. Epub 2014 Mar 22.
Proton magnetic resonance spectroscopy can be used to assess brain integrity and maturation with age.
To compare regional cerebral magnetic resonance spectroscopy metabolite ratios in extremely low birth weight and healthy term control infants measured at term-equivalent age and to evaluate association between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age.
Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants. Magnetic resonance spectroscopy metabolite ratios of N-acetylaspartate to choline-containing compounds and N-acetylaspartate to myo-inositiol in the hippocampus, cortex, and subventricular zone were associated with Bayley mental, cognitive, and language scores at 18-22 months' corrected age.
The mean (±S.D.) gestation of the 31 extremely low birth weight population was 25 (±1.1) weeks and mean (±S.D.) birth weight was 749 (±133.9) g. Compared with healthy term control infants, extremely low birth weight infants exhibited consistently lower N-acetylaspartate-to-choline-containing compounds ratios in our three regions of interest, with differences reaching statistical significance for the subventricular zone and cortex regions. In multiple linear regression analyses, N-acetylaspartate-to-choline-containing compounds ratio in the subventricular zone, N-acetylaspartate-to-choline-containing compounds ratio in the cortex, and N-acetylaspartate-to-myo-inositiol ratio in the subventricular zone were significantly associated with Bayley mental scores at 18-22 months' corrected age.
Magnetic resonance spectroscopy metabolite abnormalities at term-equivalent age appear to be significantly associated with cognitive and language development in extremely low birth weight infants.
质子磁共振波谱可用于评估大脑完整性及随年龄的成熟情况。
比较极早早产儿和足月健康对照婴儿在足月矫正年龄时测量的局部脑磁共振波谱代谢物比率，并评估在矫正年龄18至22个月时磁共振波谱代谢物与认知和语言发育之间的关联。
对43例婴儿的前瞻性队列进行单体素质子磁共振波谱序列检查。海马体、皮质和脑室下区中N-乙酰天门冬氨酸与含胆碱化合物的比率以及N-乙酰天门冬氨酸与肌醇的磁共振波谱代谢物比率与矫正年龄18至22个月时的贝利智力、认知和语言评分相关。
31例极早早产儿的平均（±标准差）孕周为25（±1.1）周，平均（±标准差）出生体重为749（±133.9）g。与足月健康对照婴儿相比，极早早产儿在我们感兴趣的三个区域中N-乙酰天门冬氨酸与含胆碱化合物的比率始终较低，脑室下区和皮质区域的差异具有统计学意义。在多元线性回归分析中，脑室下区N-乙酰天门冬氨酸与含胆碱化合物的比率、皮质中N-乙酰天门冬氨酸与含胆碱化合物的比率以及脑室下区N-乙酰天门冬氨酸与肌醇的比率与矫正年龄18至22个月时的贝利智力评分显著相关。
足月矫正年龄时的磁共振波谱代谢物异常似乎与极早早产儿的认知和语言发育显著相关。
