Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, China.
Metabolism. 2012 Jun;61(6):891-7. doi: 10.1016/j.metabol.2011.10.022. Epub 2011 Dec 28.
The angiotensin-1-converting enzyme (ACE) gene has been suggested to be involved in the development of metabolic syndrome (MetS). However, results have been inconsistent. In this study, a meta-analysis was performed to investigate the association between ACE insertion/deletion (I/D) polymorphism and MetS. Published literature from PubMed, EMBASE, and ISI Web of Science databases was searched for eligible publications. All studies assessing the association between ACE I/D polymorphism and MetS were included. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated using a fixed- or random-effects model. Ten studies (1939 cases/2845 controls) for ACE I/D polymorphism were included in this meta-analysis. Most of the studies were performed in whites. The ACE I/D polymorphism was associated with an increased OR of MetS under a dominant model (DD + ID vs II: OR = 1.39; 95% CI, 1.22-1.60; P < .001). Using this model, similar results were found among studies using different ethnic populations, studies using different MetS definitions, and studies with more than 100 cases. This meta-analysis indicated that the D allele of the ACE gene, known to be related to higher levels of angiotensinogen, is associated with an increased OR of MetS. However, given the limited sample size, this association warrants further investigation.
血管紧张素转换酶（ACE）基因被认为与代谢综合征（MetS）的发生有关。然而，研究结果并不一致。本研究采用荟萃分析方法，旨在探讨 ACE 插入/缺失（I/D）多态性与 MetS 之间的关系。通过 PubMed、EMBASE 和 ISI Web of Science 数据库检索符合条件的文献，所有评估 ACE I/D 多态性与 MetS 相关性的研究均被纳入。采用固定或随机效应模型计算合并优势比（OR）及其相应的 95%置信区间（CI）。该荟萃分析纳入了 10 项 ACE I/D 多态性研究（1939 例病例/2845 例对照）。这些研究大多在白种人群中进行。在显性模型（DD + ID 与 II 相比：OR = 1.39；95%CI，1.22-1.60；P <.001）下，ACE I/D 多态性与 MetS 的 OR 升高相关。采用该模型，在使用不同种族人群、不同 MetS 定义和病例数超过 100 例的研究中，均得到了相似的结果。该荟萃分析表明，ACE 基因的 D 等位基因与较高水平的血管紧张素原有关，与 MetS 的 OR 升高相关。然而，鉴于样本量有限，该关联需要进一步研究。
