Department of Rehabilitation Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, Germany.
Rheumatol Int. 2012 Sep;32(9):2593-9. doi: 10.1007/s00296-011-2348-2. Epub 2011 Dec 31.
Fibromyalgia syndrome (FMS) is a common chronic pain condition characterized by chronic widespread pain and decreased pain threshold, with hyperalgesia and allodynia. Associated signs include fatigue, morning stiffness, non-restorative sleep, mood disturbance, depression, irritable bowel syndrome, and headache. In addition to the administration of drugs, psychological therapies treatment of FMS mainly consists of physical therapies. Although the precise pathogenesis of FMS remains elucidated, modern understanding conceptualizes FMS as central sensitization as a consequence of altered endogenous pain- and stress-response system and continuous nociceptive input. Altered brain-derived neurotrophic factor (BDNF) levels in FMS suggest that BDNF--well known for its effects on neuronal plasticity--is involved in this sensitization process. Exercise leads to changes in serum BDNF levels, too. This association highlights the importance of exercise in FMS and other chronic pain conditions.
纤维肌痛综合征（FMS）是一种常见的慢性疼痛疾病，其特征为慢性广泛性疼痛和痛觉阈值降低，伴有痛觉过敏和感觉异常。相关症状包括疲劳、晨僵、睡眠质量不佳、情绪紊乱、抑郁、肠易激综合征和头痛。除了药物治疗外，FMS 的心理治疗主要包括物理治疗。尽管 FMS 的确切发病机制仍未阐明，但现代认识将其概念化为中枢敏化，这是内源性疼痛和应激反应系统改变以及持续伤害性传入的结果。FMS 中脑源性神经营养因子（BDNF）水平的改变表明，BDNF——因其对神经元可塑性的影响而广为人知——参与了这一敏化过程。运动也会导致血清 BDNF 水平的变化。这种关联突出了运动在 FMS 和其他慢性疼痛疾病中的重要性。
