Landers B R, Devitt P G, Jamieson G G
Department of Surgery, University of Adelaide, South Australia.
Am J Physiol. 1990 Oct;259(4 Pt 1):G676-80. doi: 10.1152/ajpgi.1990.259.4.G676.
The emptying of a 400-g test meal of cubed liver was studied in eight pigs equipped with duodenal cannulas. Gastric effluent was diverted to measure both the rate of emptying and the distribution of particle sizes. The effect of emptying and particle size of infusing normal saline or an isosmolar amino acid solution into the small bowel was studied. Normal saline infusion did not alter the proportion of particles emptied, which were less than 1 mm in diameter. Infusion of the amino acid solution at the same rate significantly decreased the mass of liver emptied from 69.9 to 38.4 g compared with normal saline, and the percentage of particles less than 1 mm in diameter in the gastric effluent increased from 66 to 82%. We conclude that the amino acid solution produced both a reduction in the rate of gastric emptying and an increase in the proportion of small particles in the gastric effluent. We postulate that this may have been due to changes in gastric motility, together with alterations in gastric secretion and digestion, produced by the infusion of the amino acid solution into the small bowel.
在八头装有十二指肠插管的猪身上研究了400克切成小块的肝脏测试餐的排空情况。将胃流出物引出以测量排空速率和颗粒大小分布。研究了向小肠内输注生理盐水或等渗氨基酸溶液对排空和颗粒大小的影响。输注生理盐水并未改变直径小于1毫米的已排空颗粒的比例。以相同速率输注氨基酸溶液与输注生理盐水相比，显著降低了肝脏排空质量，从69.9克降至38.4克，胃流出物中直径小于1毫米的颗粒百分比从66%增加到82%。我们得出结论，氨基酸溶液既降低了胃排空速率，又增加了胃流出物中小颗粒的比例。我们推测，这可能是由于向小肠内输注氨基酸溶液导致胃动力改变，以及胃分泌和消化改变所致。
