Dass Ashwitha Shruti, Narayana Sarala, Venkatarathnamma P N
Department of Pharmacology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.
Department of Medicine, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.
J Adv Pharm Technol Res. 2018 Jan-Mar;9(1):32-36. doi: 10.4103/japtr.JAPTR_309_17.
Diabetes mellitus (DM) and its complications have been implicated in hyperglycemia-induced oxidative stress. Antioxidants can improve glycemic control, lipid profile, and cognitive functions. We assessed the effect of Vitamin E and omega 3 fatty acids (OFA) on the above parameters. One hundred patients with type 2 DM receiving metformin 500 mg and glimepiride 1 mg were randomized to receive add-on therapy of Vitamin E 400 mg or OFA once daily for 12 weeks and the third group served as control. Fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), body mass index (BMI), waist-hip ratio (WHR), lipid profile, and mini-mental state examination were done at baseline and 12 weeks. Eighty-seven patients completed the study. A significant reduction in FBS, PPBS, and HbA1c was observed in all the three groups at 12 weeks. There was significant reduction in total cholesterol and triglycerides (TG) in patients receiving either of the antioxidants and also significant reduction in low-density lipoprotein in patients receiving OFA at 12 weeks compared to baseline. BMI and WHR were significantly increased in control group. Intergroup analysis showed that in patients receiving Vitamin E and OFA, the reduction of FBS, PPBS, and HbA1c were similar. The patients receiving OFA had significant reduction in TG compared to control. There was no significant effect on cognitive function. Vitamin E and OFA had beneficial effects on lipid profile and anthropometric measurements; however, the glycemic control was similar to the patients in control group.
糖尿病（DM）及其并发症与高血糖诱导的氧化应激有关。抗氧化剂可改善血糖控制、血脂水平和认知功能。我们评估了维生素E和ω-3脂肪酸（OFA）对上述参数的影响。100例接受500mg二甲双胍和1mg格列美脲治疗的2型糖尿病患者被随机分为三组，分别接受每日一次400mg维生素E或OFA的附加治疗，为期12周，第三组作为对照组。在基线和12周时测量空腹血糖（FBS）、餐后血糖（PPBS）、糖化血红蛋白（HbA1c）、体重指数（BMI）、腰臀比（WHR）、血脂水平和简易精神状态检查。87例患者完成了研究。在12周时，所有三组的FBS、PPBS和HbA1c均显著降低。与基线相比，接受任何一种抗氧化剂治疗的患者总胆固醇和甘油三酯（TG）均显著降低，接受OFA治疗的患者在12周时低密度脂蛋白也显著降低。对照组的BMI和WHR显著增加。组间分析显示，接受维生素E和OFA治疗的患者，FBS、PPBS和HbA1c的降低情况相似。与对照组相比，接受OFA治疗的患者TG显著降低。对认知功能无显著影响。维生素E和OFA对血脂水平和人体测量指标有有益影响；然而，血糖控制与对照组患者相似。
