State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
Int J Biol Sci. 2012;8(1):30-8. doi: 10.7150/ijbs.8.30. Epub 2011 Nov 9.
Infections can influence bone metabolism of neonates, which may lead to changes in some bone metabolism biomarkers. The purpose of this study was to determine whether serum bone alkaline phosphatase (BALP), osteocalcin (OC) and beta carboxy-terminal peptide of type I collagen (CTX), as specific biomarkers of bone metabolism, can be used to assess the severity of neonatal infections.
Sixty-three neonates in the NICU were enrolled in this study. The neonates were divided into infected group (n=33) and non-infected group (n=30). The scores for neonatal acute physiology-perinatal extension II (SNAPPE-II) were calculated and interleukin-6 (IL-6), procalcitonin (PCT), BALP, OC and CTX were measured among the neonates with or without infections, and among the infected neonates before and after treatment.
The serum BALP levels were lower in the infected group than that in the non-infected group (p<0.01). The serum BALP levels increased markedly in the infected neonates after treatment (p<0.01). The serum BALP levels were also inversely correlated with SNAPPE-II of infected neonates before and after treatment (r=-0.56, p<0.05; r=-0.37, p<0.05, respectively). In infected neonates, the differences between serum BALP levels before and after treatment were inversely correlated with those of IL-6 levels (p<0.05). There were no significant changes in the OC, CTX and PCT levels in the infected or non-infected group before and after treatment.
Our data suggest that serum BALP level might be used as a marker for assessing the severity of illness in infected neonates.
感染可影响新生儿的骨代谢，这可能导致一些骨代谢生物标志物发生变化。本研究旨在确定血清骨碱性磷酸酶（BALP）、骨钙素（OC）和 I 型胶原羧基端肽（CTX）等骨代谢特异性生物标志物是否可用于评估新生儿感染的严重程度。
本研究纳入了新生儿重症监护病房（NICU）中的 63 例新生儿。将新生儿分为感染组（n=33）和非感染组（n=30）。计算新生儿急性生理学与围产期扩展 II 评分（SNAPPE-II），并测量感染组和非感染组新生儿以及感染新生儿治疗前后的白细胞介素 6（IL-6）、降钙素原（PCT）、BALP、OC 和 CTX。
感染组新生儿的血清 BALP 水平低于非感染组（p<0.01）。感染新生儿治疗后血清 BALP 水平显著升高（p<0.01）。感染新生儿治疗前后的血清 BALP 水平与 SNAPPE-II 呈负相关（r=-0.56，p<0.05；r=-0.37，p<0.05）。在感染新生儿中，治疗前后血清 BALP 水平的差异与 IL-6 水平的差异呈负相关（p<0.05）。感染组和非感染组新生儿治疗前后 OC、CTX 和 PCT 水平均无显著变化。
我们的数据表明，血清 BALP 水平可作为评估感染新生儿严重程度的标志物。
