ETEP Research Group, University Complutense, Madrid, Spain.
Clin Oral Implants Res. 2012 Feb;23 Suppl 5:22-38. doi: 10.1111/j.1600-0501.2011.02331.x.
This systematic review aims to evaluate the scientific evidence on the efficacy in the surgical protocols designed for preserving the alveolar ridge after tooth extraction and to evaluate how these techniques affect the placement of dental implants and the final implant supported restoration.
A thorough search in MEDLINE-PubMed, Embase and the Cochrane Central Register of controlled trials (CENTRAL) was conducted up to February 2011. Randomized clinical trials and prospective cohort studies with a follow-up of at least 3 months reporting changes on both the hard and soft tissues (height and/or width) of the alveolar process (mm or %) after tooth extraction were considered for inclusion.
The screening of titles and abstracts resulted in 14 publications meeting the eligibility criteria. Data from nine of these 14 studies could be grouped in the meta-analyses. Results from the meta-analyses showed a statistically significant greater ridge reduction in bone height for control groups as compared to test groups (weighted mean differences, WMD = -1.47 mm; 95% CI [-1.982, -0.953]; P < 0.001; heterogeneity: I(2) = 13.1%; χ(2) P-value = 0.314) and a significant greater reduction in bone width for control groups compared to the test groups (WMD = -1.830 mm; 95% CI [-2.947, -0.732]; P = 0.001; heterogeneity: I(2) = 0%; χ(2) P-value = 0.837). Subgroup analysis was based on the surgical protocol used for the socket preservation (flapless/flapped, barrier membrane/no membrane, primary intention healing/no primary healing) and on the measurement method utilized to evaluate morphological changes. Meta-regression analyses demonstrated a statistically significant difference favoring the flapped subgroup in terms of bone width (meta-regression; slope = 2.26; 95% IC [1.01; 3.51]; P = 0.003).
The potential benefit of socket preservation therapies was demonstrated resulting in significantly less vertical and horizontal contraction of the alveolar bone crest. The scientific evidence does not provide clear guidelines in regards to the type of biomaterial, or surgical procedure, although a significant positive effect of the flapped surgery was observed. There are no data available to draw conclusions on the consequences of such benefits on the long-term outcomes of implant therapy.
本系统评价旨在评估拔牙后用于保存牙槽嵴的外科方案的疗效,并评估这些技术如何影响牙种植体的放置和最终的种植体支持修复。
截至 2011 年 2 月,我们在 MEDLINE-PubMed、Embase 和 Cochrane 对照试验中心注册库(CENTRAL)中进行了全面检索。我们纳入了报告拔牙后硬组织(高度和/或宽度)和软组织变化的随机临床试验和前瞻性队列研究,这些研究的随访时间至少为 3 个月。
筛选标题和摘要后,有 14 篇符合纳入标准的文献。对这 14 项研究中的 9 项研究的数据进行了荟萃分析。荟萃分析结果显示,对照组的牙槽嵴高度减少量显著大于试验组(加权均数差值,WMD = -1.47mm;95%CI[-1.982, -0.953];P<0.001;异质性:I(2) = 13.1%;χ(2) P 值 = 0.314),对照组的牙槽嵴宽度减少量也显著大于试验组(WMD = -1.830mm;95%CI[-2.947, -0.732];P = 0.001;异质性:I(2) = 0%;χ(2) P 值 = 0.837)。亚组分析基于用于牙槽窝保存的手术方案(无瓣/有瓣、屏障膜/无膜、一期愈合/非一期愈合)和用于评估形态变化的测量方法。Meta 回归分析显示,在牙槽嵴宽度方面,有瓣亚组具有统计学意义上的优势(Meta 回归;斜率=2.26;95%IC[1.01;3.51];P = 0.003)。
牙槽窝保存治疗的潜在益处表现为牙槽骨嵴的垂直和水平收缩明显减少。虽然观察到有瓣手术的显著积极效果,但科学证据并未提供关于生物材料类型或手术程序的明确指导。目前尚无数据可得出关于此类益处对种植体治疗长期结果的影响的结论。