Chandra S A, Gilbert E F, Viseskul C, Strother C M, Haning R V, Javid M J
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison.
Arch Pathol Lab Med. 1990 Oct;114(10):1079-82.
A 1-month-old infant died from extensive intracerebral hemorrhage due to a metastatic choriocarcinoma to the brain that presumably originated in the placenta. The clinical course was characterized by hyperbilirubinemia, repeated episodes of seizures, and intracranial hemorrhage. A computed tomographic scan revealed a large vascular mass in the left parieto-occipital region and a small lesion in the left frontal lobe. The placenta was expelled during the delivery and was not examined. In view of the high level of maternal human chorionic gonadotropic hormone and the autopsy finding of metastasis, we presumed that the mass was a metastatic choriocarcinoma that had originated in the maternal placenta. To our knowledge, only one previous instance of this phenomenon has been reported.
一名1个月大的婴儿死于广泛的脑出血，脑出血是由脑转移性绒毛膜癌引起的，推测该肿瘤起源于胎盘。临床病程的特征为高胆红素血症、反复发作的癫痫和颅内出血。计算机断层扫描显示左顶枕区有一个大的血管性肿块，左额叶有一个小病灶。胎盘在分娩时排出，未进行检查。鉴于母体人绒毛膜促性腺激素水平较高以及尸检发现有转移，我们推测该肿块是起源于母体胎盘的转移性绒毛膜癌。据我们所知，此前仅报道过一例这种现象。
