Zimatkin S M
Arkh Anat Gistol Embriol. 1989 Jan;96(1):35-40.
By means of the quantitative histochemical method aldehyde dehydrogenase (AldDG; acidic phosphatase 1.2.1.3.) activity has been studied in neuronal structures of all parts of the rat CNS. The greatest activity has been revealed in cytoplasm of receptor (nucleus of the mesencephalic tract trigeminal nerve-1,100 stipulated units) and effector (all motor nuclei of the trunk and spinal cord: 500-800 stipulated units) cerebral neurons. In perikaryons and axons of most of the intercalated neurons AldDG activity is not great (200-300 stipulated units). A positive correlation is found between distribution of AldDG activity among the forebrain structures, on the one hand, and density of dopaminergic terminals, dopamine content and MAO activity of these structures--on the other. In the metencephalon similar correlation is found between AldDG activity and noradrenaline content and density of serotoninergic terminals. A direct dependence is stated of AldDG activity on phylogenic age of the cerebral structures. The data presented demonstrate that AldDG activity is connected with those cerebral structures that are supposed to possess, in the process of common and mediatory metabolism, a high level of natural synthesis of aldehydes.
通过定量组织化学方法，对大鼠中枢神经系统各部分神经元结构中的醛脱氢酶（AldDG；酸性磷酸酶1.2.1.3.）活性进行了研究。在受体（三叉神经中脑束核 - 1100个规定单位）和效应器（躯干和脊髓的所有运动核：500 - 800个规定单位）脑神经元的细胞质中发现了最高活性。在大多数中间神经元的胞体和轴突中，AldDG活性不高（200 - 300个规定单位）。一方面，在前脑结构中AldDG活性分布与这些结构的多巴胺能终末密度、多巴胺含量和MAO活性之间存在正相关；另一方面，在脑桥中，AldDG活性与去甲肾上腺素含量和5 - 羟色胺能终末密度之间也存在类似的相关性。AldDG活性直接依赖于脑结构的系统发生年龄。所呈现的数据表明，AldDG活性与那些在共同和介导代谢过程中被认为具有高水平醛类天然合成的脑结构有关。
