Aso S
Second Department of Medicine, Kurume University School of Medicine.
Arukoru Kenkyuto Yakubutsu Ison. 1990 Jun;25(3):168-79.
Significance of the antibody to alcohol altered hepatocyte plasma membrane (AAHM) was studied in various types of alcoholic liver diseases (ALD). AAHM was detected in the sera that were collected within 3 months of alcohol abstinence from patients with various types of ALD, with higher frequency in alcoholic hepatitis and cirrhosis. Serum acetaldehyde, gamma-globulin fraction, immunoglobulin A and G were higher in patients positive for AAHM, though the levels of GOT, GPT, mGOT were indifferent of the existence of AAHM. Histologically, hepatocyte ballooning and pericellular fibrosis were frequently seen in patients positive for AAHM, but close relationship between the extent of necrosis and existence of AAHM was not observed. These findings suggest that the occurrence of AAHM is closely related with the functional and morphological changes of the hepatocyte induced by acetaldehyde but not with hepatocyte necrosis.
研究了酒精改变肝细胞质膜抗体（AAHM）在各种类型酒精性肝病（ALD）中的意义。在各类ALD患者戒酒3个月内采集的血清中检测到AAHM，在酒精性肝炎和肝硬化患者中出现频率更高。AAHM阳性患者的血清乙醛、γ-球蛋白组分、免疫球蛋白A和G水平较高，不过谷草转氨酶（GOT）、谷丙转氨酶（GPT）、线粒体谷草转氨酶（mGOT）水平与AAHM的存在无关。组织学上，AAHM阳性患者经常可见肝细胞气球样变和细胞周围纤维化，但未观察到坏死程度与AAHM存在之间的密切关系。这些发现表明，AAHM的出现与乙醛诱导的肝细胞功能和形态变化密切相关，而与肝细胞坏死无关。
