School of Chemistry and Chemical Engineering, Southwest University, Chongqing, People's Republic of China.
Luminescence. 2012 Nov-Dec;27(6):478-81. doi: 10.1002/bio.1378. Epub 2011 Dec 30.
The chemiluminescence (CL) reaction of acyclovir (ACV)-potassium permanganate, with formaldehyde as an enhancer, was investigated by the flow-injection system, and a new method is reported for the determination of ACV on the basis of the reaction. The method is rapid, effective and simple for the determination of acyclovir in the range 0.2-80 mg/L, with a limit of detection of 0.06 mg/L (3 S:N), a relative standard deviation (RSD) of 3.7% for the determination of 1.0 mg/L acyclovir solution in 11 repeated measurements. The method has been applied to the determination of acyclovir in pharmaceuticals, with satisfactory results. The possible reaction mechanism is also discussed briefly.
阿昔洛韦-高锰酸钾的化学发光（CL）反应，以甲醛作为增强剂，通过流动注射系统进行了研究，并基于该反应报道了一种新的测定阿昔洛韦的方法。该方法快速、有效、简单，可在 0.2-80mg/L 的范围内测定阿昔洛韦，检测限为 0.06mg/L（3S:N），11 次重复测定 1.0mg/L 阿昔洛韦溶液的相对标准偏差（RSD）为 3.7%。该方法已应用于药物中阿昔洛韦的测定，结果令人满意。还简要讨论了可能的反应机制。
