Rice M, Holland L, Wagner E K
Arch Virol. 1979;59(4):345-55. doi: 10.1007/BF01317474.
HSV-1 replication and synthesis of viral DNA and RNA have been examined in gliomas of human (COX) and rat origin (C6) and in mouse neuroblastomas (D2). COX cells fully support HSV-1 replication and show patterns of viral DNA and RNA synthesis similar to those seen in continuous line cells. HSV-1 also grows to high titers in D2 cells but without concomitant high levels of viral DNA and RNA synthesis in the infected cells. Finally, HSV-1 established a persistent infection in C6 cells. Viral mRNA and DNA synthesis could not be detected in these cultures. At cycles of approximately 15--20 days, the persistently infected cultures exhibited massive CPE and relatively high production of infectious HSV.
已经在源自人类的胶质瘤（COX）、大鼠的胶质瘤（C6）以及小鼠神经母细胞瘤（D2）中检测了单纯疱疹病毒1型（HSV-1）的复制以及病毒DNA和RNA的合成。COX细胞完全支持HSV-1复制，并显示出与连续传代细胞中所见相似的病毒DNA和RNA合成模式。HSV-1在D2细胞中也能生长到高滴度，但受感染细胞中病毒DNA和RNA合成水平并未随之升高。最后，HSV-1在C6细胞中建立了持续感染。在这些培养物中未检测到病毒mRNA和DNA合成。在大约15 - 20天的周期内，持续感染的培养物表现出大量细胞病变效应（CPE）以及相对较高的传染性HSV产量。
