Department of Pathology, University of New Mexico School of Medicine, 1 University of New Mexico, Albuquerque, NM 87131, USA.
Infect Genet Evol. 2012 Mar;12(2):181-90. doi: 10.1016/j.meegid.2011.11.014. Epub 2011 Dec 27.
West Nile virus (WNV) (Flaviviridae: Flavivirus) is transmitted from mosquitoes to birds, but can cause fatal encephalitis in infected humans. Since its introduction into North America in New York in 1999, it has spread throughout the western hemisphere. Multiple outbreaks have also occurred in Europe over the last 20 years. This review highlights recent efforts to understand how host pressures impact viral population genetics, genotypic and phenotypic changes which have occurred in the WNV genome as it adapts to this novel environment, and molecular epidemiology of WNV worldwide. Future research directions are also discussed.
西尼罗河病毒(WNV)(黄病毒科:黄病毒属)通过蚊子传播给鸟类,但可导致受感染的人类发生致命性脑炎。自 1999 年在纽约的北美引入以来,它已传播到西半球各地。在过去的 20 年中,欧洲也多次爆发了这种病毒。这篇综述强调了最近在了解宿主压力如何影响病毒群体遗传学方面的努力,以及 WNV 基因组适应这种新环境时发生的基因型和表型变化,以及 WNV 在全球的分子流行病学。还讨论了未来的研究方向。