原核生物中 DNA 易位的分子马达。
Molecular motors for DNA translocation in prokaryotes.
机构信息
Laboratoire de Physique Statistique, Ecole Normale Supérieure, UMR 8550 CNRS, Universités Pierre et Marie Curie and Paris Diderot, Département de Physique, 24 rue Lhomond, 75231 Paris Cedex 05, France.
出版信息
Curr Opin Biotechnol. 2012 Aug;23(4):503-9. doi: 10.1016/j.copbio.2011.12.023. Epub 2012 Jan 7.
Abstract
DNA transport is an essential life process. From chromosome separation during cell division or sporulation, to DNA virus ejection or encapsidation, to horizontal gene transfer, it is ubiquitous in all living organisms. Directed DNA translocation is often energetically unfavorable and requires an active process that uses energy, namely the action of molecular motors. In this review we present recent advances in the understanding of three molecular motors involved in DNA transport in prokaryotes, paying special attention to recent studies using single-molecule techniques. We first discuss DNA transport during cell division, then packaging of DNA in phage capsids, and then DNA import during bacterial transformation.
摘要
DNA 运输是一种基本的生命过程。从细胞分裂或孢子形成过程中的染色体分离，到 DNA 病毒的排出或包裹，再到水平基因转移，它在所有生物中无处不在。定向 DNA 易位通常在能量上是不利的，需要一个利用能量的主动过程，即分子马达的作用。在这篇综述中，我们介绍了在原核生物中参与 DNA 运输的三种分子马达的最新研究进展，特别关注了使用单分子技术的最新研究。我们首先讨论细胞分裂过程中的 DNA 运输，然后讨论噬菌体衣壳中的 DNA 包装，然后讨论细菌转化过程中的 DNA 导入。
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