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副肿瘤性脑炎伴重症肌无力和恶性胸腺瘤。

Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma.

机构信息

Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

出版信息

J Clin Neurosci. 2012 Feb;19(2):336-8. doi: 10.1016/j.jocn.2011.05.026. Epub 2012 Jan 9.

Abstract

We present a patient with type B2 thymoma (World Health Organization Thymoma Classification) with the complications of anti-muscle acetylcholine receptor antibody-positive myasthenia gravis and anti-voltage-gated potassium channel antibodies associated with paraneoplastic encephalitis. A timing difference between the onset of these neurological disorders and a dissociation of clinical symptoms was observed during the disease. This report alerts clinicians that long-term follow-up is needed where patients have a residual thymoma and attention should be paid to other concomitant autoimmune disorders.

摘要

我们报告了 1 例 B2 型胸腺瘤(世界卫生组织胸腺瘤分类)患者,该患者合并抗肌肉乙酰胆碱受体抗体阳性的重症肌无力和抗电压门控钾通道抗体相关的副肿瘤性脑炎。在疾病过程中观察到这些神经障碍的发病时间不同,且临床症状分离。本报告提醒临床医生,对于有残余胸腺瘤的患者需要进行长期随访,并应注意其他同时存在的自身免疫性疾病。

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