Devi V Kusum, Jain Nimisha, Valli Kusum S
Al-Ameen College of Pharmacy, Bangalore, India.
Pharmacogn Rev. 2010 Jan;4(7):27-31. doi: 10.4103/0973-7847.65322.
Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. Our country has a vast knowledge base of Ayurveda whose potential is only being realized in the recent years. However, the drug delivery system used for administering the herbal medicine to the patient is traditional and out-of-date, resulting in reduced efficacy of the drug. If the novel drug delivery technology is applied in herbal medicine, it may help in increasing the efficacy and reducing the side effects of various herbal compounds and herbs. This is the basic idea behind incorporating novel method of drug delivery in herbal medicines. Thus it is important to integrate novel drug delivery system and Indian Ayurvedic medicines to combat more serious diseases. For a long time herbal medicines were not considered for development as novel formulations owing to lack of scientific justification and processing difficulties, such as standardization, extraction and identification of individual drug components in complex polyherbal systems. However, modern phytopharmaceutical research can solve the scientific needs (such as determination of pharmacokinetics, mechanism of action, site of action, accurate dose required etc.) of herbal medicines to be incorporated in novel drug delivery system, such as nanoparticles, microemulsions, matrix systems, solid dispersions, liposomes, solid lipid nanoparticles and so on. This article summarizes various drug delivery technologies, which can be used for herbal actives together with some examples.
新型药物递送系统是一种新型的药物递送方法，它解决了传统药物递送系统的局限性。我国拥有庞大的阿育吠陀知识库，其潜力直到最近几年才被认识到。然而，用于给患者施用草药的药物递送系统是传统且过时的，导致药物疗效降低。如果将新型药物递送技术应用于草药，可能有助于提高各种草药化合物和草药的疗效并减少其副作用。这就是在草药中纳入新型药物递送方法背后的基本理念。因此，整合新型药物递送系统和印度阿育吠陀药物以对抗更严重的疾病很重要。长期以来，由于缺乏科学依据以及加工困难，如标准化、提取和鉴定复杂多草药系统中的单个药物成分等，草药未被考虑开发成新型制剂。然而，现代植物药研究可以解决将草药纳入新型药物递送系统（如纳米颗粒、微乳、基质系统、固体分散体、脂质体、固体脂质纳米颗粒等）的科学需求（如药代动力学测定、作用机制、作用部位、所需准确剂量等）。本文总结了各种可用于草药活性成分的药物递送技术，并列举了一些实例。
