Ekçi Baki, Karabicak Ihsan, Atukeren Pinar, Altinlio Ediz, Tomaoglu Kamer, Tasci Ihsan
Medical School of Yeditepe University, Department of General Surgery, Istanbul, Turkey.
Ann Ital Chir. 2011 Nov-Dec;82(6):475-9.
Many systemic and local factors contribute to gastrointestinal tract anastomoses dehiscence, which is a serious and potentially fatal postoperative complication. The aim of this study was to evaluate the effects of omega-3 fatty acid and ascorbic acid on the healing of ischemic colon anastomosis.
40 Wistar Albino rats weighing between 180 and 220 g were divided into four groups. Groups were assigned as follows; Group 1 (control): anastomosis and no treatment, Group 2: anastomosis plus ascorbic acid, Group 3: anastomosis plus omega-3 fatty acid, and Group 4: anastomosis plus ascorbic acid and omega-3 fatty acid. Colon anastomoses was were performed in all rats. All animals were sacrificed on the 5th postoperative day. Healing of the anastomoses was assessed by measuring the burst pressures (BP) and hydroxyproline levels.
No mortality was observed and perianastomotic abscesses were not noted in any rats. The BP was significantly higher in the ascorbic acid plus omega-3 fatty acid combination group than the other groups (p < 0.05). The hydroxyproline levels were significantly high in ascorbic acid plus omega-3 fatty acid combination group than the other groups (p < 0.05).
Dietary supplementation with omega-3 fatty acid and ascorbic acid improved colonic anastomoses healing. Ascorbic acid and omega-3 fatty acid enhance the colonic wound healing process by additive action.
许多全身和局部因素都会导致胃肠道吻合口裂开，这是一种严重且可能致命的术后并发症。本研究的目的是评估ω-3脂肪酸和抗坏血酸对缺血性结肠吻合口愈合的影响。
将40只体重在180至220克之间的Wistar白化大鼠分为四组。分组如下：第1组（对照组）：进行吻合术但不治疗；第2组：吻合术加抗坏血酸；第3组：吻合术加ω-3脂肪酸；第4组：吻合术加抗坏血酸和ω-3脂肪酸。对所有大鼠进行结肠吻合术。所有动物在术后第5天处死。通过测量破裂压力（BP）和羟脯氨酸水平评估吻合口的愈合情况。
未观察到死亡情况，且所有大鼠均未发现吻合口周围脓肿。抗坏血酸加ω-3脂肪酸联合组的BP显著高于其他组（p < 0.05）。抗坏血酸加ω-3脂肪酸联合组的羟脯氨酸水平显著高于其他组（p < 0.05）。
饮食中补充ω-3脂肪酸和抗坏血酸可改善结肠吻合口的愈合。抗坏血酸和ω-3脂肪酸通过相加作用增强结肠伤口愈合过程。
