Department of Health Systems, Management & Policy, Colorado School of Public Health, Children's Outcomes Research Group, Children's Hospital Colorado, Aurora, USA.
Acad Pediatr. 2012 Mar-Apr;12(2):96-103. doi: 10.1016/j.acap.2011.11.004. Epub 2012 Jan 9.
To determine the effectiveness of policy-driven therapy (ie, Part C early intervention [EI]) in the context of varying maternal supports among preterm infants in Wisconsin.
A longitudinal study of mother-infant dyads recruited from 3 newborn intensive care units in southeastern Wisconsin. Participation in EI-based therapy was collected at 36 months via parent-report. Cognitive function was measured at 16 months by use of the Bayley Scales of Infant Development (Mental Developmental Index), 2nd edition and at 24 and 36 months postterm via use of the Stanford-Binet Intelligence scale, 5th edition. Maternal support was measured at 4 months with the Maternal Support Scale. Propensity score matching was used to reduce selection bias. Latent growth models of matched pairs estimated the effect of EI therapy on cognitive function trajectories. Ordinary least squares regression estimated the differential effect of EI therapy on cognitive function at 16, 24, and 36 months postterm for mothers reporting more maternal supports.
Of the 128 infants, 41 received EI therapy and, of those, 32 (78%) were successfully matched with controls. The results of the matched analysis (n = 64) reveal that 1) receipt of therapy is inversely associated with cognitive function baseline (P = .04) and positively associated with trajectories (P = .03), 2) the number of maternal supports is positively associated with cognitive function for families receiving Part C early intervention, at 16 months (P = .05), 24 months (P < .01), and 36 months (P = .05) postterm.
Participation in EI therapy may be associated with more optimal cognitive function trajectories. Among preterm children whose mothers have more supports, receiving therapy appears particularly beneficial.
在威斯康星州,通过评估不同程度的产妇支持,研究政策驱动治疗(即 C 部分早期干预[EI])对早产儿的治疗效果。
这是一项对来自威斯康星东南部 3 家新生儿重症监护病房的母婴对子进行的纵向研究。通过家长报告,在 36 个月时收集 EI 基础治疗的参与情况。在 16 个月时,使用贝利婴幼儿发展量表(第二版)测量认知功能,在 24 和 36 个月时,使用斯坦福-比奈智力量表(第五版)测量认知功能。在 4 个月时,使用产妇支持量表测量产妇支持情况。使用倾向评分匹配来减少选择偏倚。匹配对的潜在增长模型估计 EI 治疗对认知功能轨迹的影响。普通最小二乘法回归估计报告产妇支持更多的母亲中 EI 治疗对认知功能的差异效应,分别在 16、24 和 36 个月时。
在 128 名婴儿中,有 41 名接受 EI 治疗,其中 32 名(78%)成功与对照组匹配。匹配分析的结果(n=64)显示,1)接受治疗与认知功能基线呈负相关(P=0.04),与轨迹呈正相关(P=0.03),2)产妇支持的数量与接受 C 部分早期干预的家庭的认知功能呈正相关,在 16 个月(P=0.05)、24 个月(P<0.01)和 36 个月(P=0.05)时。
参与 EI 治疗可能与更理想的认知功能轨迹有关。在产妇支持较多的早产儿中,接受治疗似乎特别有益。