Department of Computer Science, University of Calgary, Calgary, AB T2N 1N4, Canada.
New Phytol. 2012 Feb;193(3):549-569. doi: 10.1111/j.1469-8137.2011.04009.x.
The use of computational techniques increasingly permeates developmental biology, from the acquisition, processing and analysis of experimental data to the construction of models of organisms. Specifically, models help to untangle the non-intuitive relations between local morphogenetic processes and global patterns and forms. We survey the modeling techniques and selected models that are designed to elucidate plant development in mechanistic terms, with an emphasis on: the history of mathematical and computational approaches to developmental plant biology; the key objectives and methodological aspects of model construction; the diverse mathematical and computational methods related to plant modeling; and the essence of two classes of models, which approach plant morphogenesis from the geometric and molecular perspectives. In the geometric domain, we review models of cell division patterns, phyllotaxis, the form and vascular patterns of leaves, and branching patterns. In the molecular-level domain, we focus on the currently most extensively developed theme: the role of auxin in plant morphogenesis. The review is addressed to both biologists and computational modelers.
计算技术的应用越来越渗透到发育生物学中，从实验数据的获取、处理和分析到生物体模型的构建。具体来说，模型有助于理清局部形态发生过程与全局模式和形态之间的非直观关系。我们调查了旨在以机械方式阐明植物发育的建模技术和选定的模型，重点介绍了：数学和计算方法在发育植物生物学中的历史；模型构建的关键目标和方法方面；与植物建模相关的各种数学和计算方法；以及两类模型的本质，它们从几何和分子角度接近植物形态发生。在几何领域，我们回顾了细胞分裂模式、叶序、叶片的形状和脉管模式以及分枝模式的模型。在分子水平域，我们专注于目前最广泛开发的主题：生长素在植物形态发生中的作用。该综述面向生物学家和计算建模师。
