Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova St,, Moscow, Russian Federation.
Ann Clin Microbiol Antimicrob. 2012 Jan 11;11:1. doi: 10.1186/1476-0711-11-1.
Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.
肠道中生活的微生物与免疫系统保持着持续接触，免疫系统可以防止感染并维持体内平衡。肠上皮α防御素在调节肠道细菌定植以及固有层适应性免疫系统细胞的促炎和抗炎反应中发挥着重要作用。本文综述了哺乳动物肠上皮α防御素在免疫防御中的作用及其在肠道炎症性疾病和癌症中分泌变化的相关数据。
