Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Surg Oncol. 2012 Jul 1;106(1):57-61. doi: 10.1002/jso.23040. Epub 2012 Jan 11.
High-mobility group box 1 (HMGB1) is a versatile protein with intranuclear and extracellular functions that is involved in numerous biological and pathological processes, such as transcription, DNA repair, and response to infection and inflammation. HMGB1 overexpression has been reported in a variety of human cancers. However, the clinical significance of HMGB1 expression in bladder cancer (BC) remains unclear. This study is aimed to investigate the correlations between HMGB1 expression and prognosis in patients with BC.
HMGB1 protein expression in 164 primary BC tissue specimens was analyzed by immunohistochemistry, and its association with clinicopathologic factors and prognosis was also analyzed.
HMGB1 protein had high expression in 87 of 164 cases of BC (53%). HMGB1 overexpression was significantly associated with tumor grade (P < 0.001), and stage (P = 0.001). The Kaplan-Meier survival analysis demonstrated that HMGB1 expression was significantly associated with shorter disease-free survival and overall survival (both P < 0.001). Multivariate analysis further demonstrated that HMGB1 was an independent prognostic factor for patients with BC.
HMGB1 might be a new molecular marker to predict the prognosis of patients with BC.
高迁移率族蛋白 B1（HMGB1）是一种多功能蛋白，具有核内和细胞外功能，参与多种生物学和病理学过程，如转录、DNA 修复以及对感染和炎症的反应。HMGB1 的过表达已在多种人类癌症中报道。然而，HMGB1 在膀胱癌（BC）中的表达的临床意义尚不清楚。本研究旨在探讨 HMGB1 表达与 BC 患者预后之间的相关性。
采用免疫组织化学法分析 164 例原发性 BC 组织标本中 HMGB1 蛋白的表达，并分析其与临床病理因素和预后的关系。
在 164 例 BC 病例中，HMGB1 蛋白高表达 87 例（53%）。HMGB1 过表达与肿瘤分级（P<0.001）和分期（P=0.001）显著相关。Kaplan-Meier 生存分析表明，HMGB1 表达与无病生存率和总生存率显著相关（均 P<0.001）。多因素分析进一步表明，HMGB1 是 BC 患者的独立预后因素。
HMGB1 可能是预测 BC 患者预后的新的分子标志物。
